Synthetic jet actuators (SJAs) are devices that control fluid flow by synthesizing surrounding fluid without altering the flow from the cavity. Before optimization, the selected diaphragm frequencies are subjected to a CFD solution using a dynamic mesh. Output parameters of selected loudspeaker-driven SJA are optimized under quiescent conditions. Comparisons are made between the best optimization candidate design point, experimental reference, and baseline CFD study before optimization. Re increases by 17% at 50Hz and 8.7% at other frequencies. St decreases by almost 30% across all frequencies. L is maximized and held over 4. Optimized design, based on response surface model, demonstrated a consistent ability to produce higher, more centralized velocity profiles.