The world is changing, and so are businesses, customers and technological advancement. With new innovations of technological advances, various new businesses have established to make themselves the market leaders just like large organisations, which are known as start-ups. Similarly, several small- and medium-sized businesses (SMEs) have also adopted the latest and innovative technologies in their businesses, to make themselves competitive and attract a large customer base. Artificial intelligence, deep learning, robotics, machine learning, Internet of Things (IoT) and blockchain technologies are the latest technologies, which are being adopted by start-ups and shall be adopted by SMEs. This chapter aims to explore and provide insights about the importance of the latest innovative technologies and their usage by the start-ups and SMEs by reviewing the literature. Indian society has adopted digitalisation and so as the start-ups and SMEs which have flourished the Indian markets and engaged the customers and it builds the brand strong and credible.