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We have investigated the crystal structure of strongly anisotropic semiconductor TlInSe2 by neutron diffraction method under high pressure upto P = 3.3 GPa. It was shown that the tetragonal phase of TlInSe2 crystal (the space group I4/mcm) is stable in the whole investigated range of pressure. The lattice parameters dependence of the pressure and the unit cell volume are obtained, the linear coefficients of compressibility and the bulk moduli are calculated. At the low pressure, obtained value of compressibility for the lattice parameter a is ka = 14.23 × 10−3 GPa−1 and for c is kc = 5.93 × 10−3 GPa−1. Obtained values for bulk modulus B0 and its pressure derivative B′ in tetragonal phase are 30(7) GPa and 4(1), respectively.