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Seventy-five samples of some Indian tobacco-products, 48 blood samples drawn from some tobacco- users and 14 blood samples from some healthy persons without having any tobacco habits were analysed for elements such as K, Ca, Fe, Cu, Zn, Mn, Sr, Se, As and Pb using Energy Dispersive X-ray Fluorescence (EDXRF) spectrometry at the Institute of Physics, Bhubaneswar. Comparison was made between the results from this work and the reported literature values. Tobacco-products were found to be enriched with multi-elements, and it was observed that the human blood-elements were slowly decreasing with respect to their increasing habits of tobacco.