In this paper, we investigated the general behaviors of the Tsallic holographic dark energy (THDE) model in general relativity. Here, we take the Bianchi VI0VI0 metric, which is homogeneous and anisotropic. We investigate the THDE models with the Hubble horizon and Granda–Oliveros (GO) cutoffs. We have studied the behavior of a few quantities, such as dark energy density (ρD,)(ρD,), matter-energy density (ρm)(ρm), and skewness parameter (γ)(γ) and discuss their physical significances. In our THDE models, the EoS parameter explains the universe’s evolution based on the value of the non-extensive or Tsallis parameter δδ. In addition, we develop the cosmographic parameters like, deceleration parameter (q)(q), jerk parameter (j)(j), lerk parameter (l)(l), snap parameter (S)(S) and maxout parameter (m)(m). We have explored the ωD−ω′D plane and the stability analysis of the THDE model by a perturbation method. We have also constructed a correspondence between the THDE model with quintessence. Some physical and geometrical behaviors of the models are also discussed.