Narrow Results

Prevotella copri is a prominent constituent of the human gastrointestinal microbiome, and its fluctuating abundance has been linked with positive and negative influences on diseases such as Parkinson’s disease and rheumatoid arthritis. Prevotella copri demonstrates flexibility against drugs. There is presently no vaccine approved by the FDA against prevotella copri,and treatment options are restricted. Hence, this research work was designed to create an in silico-based vaccine for prevotella copri.The protein sequences of two distinct strains ofprevotella copriwere retrieved from NCBI. The T-cell and B-cell epitopes were obtained and then analyzed for antigenicity, allergenicity, docking and simulation. The peptide comprises linear B-cell and T-cell epitopes from proteins identified as potential novel vaccine candidates. The molecular dynamics (MD) simulations and protein-protein docking results revealed that the vaccine exhibits strong and Sustained interaction with Toll-like receptor 4 (TLR4). The constructed sequence was integrated into the pET-30a (+) biological vehicle (vector) for subsequent analysis expression in E. coli through the SnapGene server. The constructed multi-epitopic vaccine candidate was assessed for its structural, physicochemical and immunological properties. The results demonstrated solubility, stability, antigenicity and nonallergenicity and showed a strong affinity for its target receptors. The in silico study represents a significant step forward in designing a vaccine that could effectively eliminate Prevotella copri globally.

Many human tumors cannot easily be avoided. In most cases a prophylactic vaccination prevents the tumor growth. In particular the Triplex vaccine prevented mammary carcinoma formation using a Chronic schedule, but it is not known if this schedule is minimal. A computational model named SimTriplex was able to reproduce in silico the in vivo experiments. The combination of SimTriplex and Genetic Algorithms (GA), produced a minimal vaccination schedule capable to guarantee in silico survival. This process required the use of a High Performance Computing (HPC) infrastructure for several days. In this paper we show another optimization procedure based on simulated annealing approach used to get a faster algorithm response.

A mathematical model considering two strains of hepatitis B virus (HBV) chronic carriers, to assess the impact of dose-structured imperfect vaccine, in a population, is designed and analyzed. The model is shown to have a locally and globally asymptotically stable disease-free equilibrium (DFE) whenever its associated reproduction number is numerically less than unity. Numerical analysis of the model shows that with the expected 50% minimum efficacy of the first vaccine dose, vaccinating 55% of the susceptible population with the first vaccine dose will be sufficient to effectively control the spread of hepatitis B infection. Such effective control can also be achieved if 50% of the first vaccine dose recipients take the second dose. Threshold analysis reveals that an imperfect HBV vaccine should have positive or negative population-level effect. Latin hypercube sampling–PRCC analysis illustrates that disease transmission rate, birth rate, natural death rate and proportion of children born with maternal immunity are most influential parameters in the disease dynamics. In this paper, the sensitivity analysis based on mathematical and in addition statistical techniques have been performed to determine the significance of the model parameters. It is observed that a number of the parameters play an important role to determine the magnitude of the basic reproduction number. Sensitivity analysis is achieved to determine model parameters’ importance in disease dynamics. It is observed that the reproduction number is the most responsive quantity to the potent transmission rate of HBV and in addition also vital to control the spread of the disease.

SARS Virus Mutating Into At Least Two Forms.

The Resilient SARS Bug.

Singapore Team Announces New Findings on SARS Virus.

Agenix Limited Annual Results.

Axon's Strategy Does the Trick.

Pro Medicus Records Strong Profit Performances.

AstraZeneca Launches Nexium in China.

Beijing Shuanglu Pharma Markets Recombinant Human Interleukin-II.

Shanghai Squibb Launches Tequin.

Shanghai Wanxing Biopharma to Conduct Clinical Trials on Malaria Vaccine.

Cipla Registers Anti-AIDS Drugs in South Africa.

NDDB Commercializes Rabies Vaccine.

ITRI and HP Collaborate in System Biology Bioinformatics Project.

GlaxoSmithKline Plans to Establish R&D Facility in Taiwan.

GlaxoSmithKline and OncoMed Pharmaceuticals Form Strategic Alliance to Develop Cancer Stem Cell Antibody Therapeutics.

BioArctic Neuroscience and Eisai Enter Into Exclusive Licensing Agreement with Novel Antibody Treatment for Alzheimer's Disease.

Japan Bioventures Today — Japan Animal Referral Medical Center.

Agilent Technologies Collaborates with BioNanomatrix to Develop Genetic Analysis System.

Eisai Opens Regional Clinical Research Center in Singapore.

GE Healthcare and Novavax to Develop and Market Pandemic Infuenza Solution.

Nanostart AG Marks Entry into Asia as Lead Investor in Singapore's Biomed Start-Up Curiox Biosystems.

QIAGEN and Bio*One Capital Enter into Joint Venture to Develop Molecular Diagnostics Products.

Binex and MaxCyte Collaborate on Cancer Immunotherapy Research.

AUSTRALIA — Malaria Breakthrough in Australia.

AUSTRALIA — Advances in Early Alzheimer's Diagnosis.

AUSTRALIA — Genetic Test for Epilepsy Sufferers Developed By Victoria, Australia Scientists.

AUSTRALIA — New R & D Facility Leads Way for Australian Biotech Sector.

AUSTRALIA — Australia Launches New Center to Focus on HIV Prevention, Treatment Research.

CHINA — Genomics Center Researchers Identify Key Mechanism in DNA Damage Response.

CHINA — Hemophiliacs in Guangdong Suffer From Lack of Treatment.

CHINA — Microbix to Build Flu Vaccine Plant in China.

CHINA — Applied Biosystems, 454 Life Sciences and Illumina Join 1000 Genomes Project.

INDIA — Indian Scientists Develop GM Mice Through Transgenic Sperm.

JAPAN — Experts Identify Genes for Bird Flu Replication.

JAPAN — Boosting Survival of Insulin-cell Transplants For Type 1 Diabetes.

JAPAN — Medtronic Launches First Insertable Cardiac Monitor in Japan.

JAPAN — Sewing DNA Thread with Lasers, Hooks and Microbobbins.

KOREA — CSD Korea launches its Patient Longitudinal Database.

NEW ZEALAND — NZ Signs Science Agreement with EU.

SINGAPORE — Singapore Researchers Identify Viral Factor That Induces Deadly Fungal Infection.

SINGAPORE — Singapore, Indonesia Enhance Collaboration to Fight Bird Flu.

SINGAPORE — Singapore Scientists Beat More Than 140 Teams to Claim Top Award at 46th American Society of Neuroradiology 2008 Meeting.

TAIWAN — Government Plans Development of Five Bio-Agricultural Parks.

TAIWAN — Local Researchers Cast New Light on Genetic Mutations.

TAIWAN — Enterovirus Cases Hit Record High.

VIETNAM — New Cholera Outbreaks in Vietnam.

VIETNAM — Vietnam, WB Join Hands to Improve Health Services in Remote Areas.

AUSTRALIA – First iPS Cell Line Puts Australia in the Lead of Stem Cell Research.

AUSTRALIA – New Treatment Hope for Prostate Cancer.

CHINA – AIDS Is China's Top Killer Among Infectious Diseases.

CHINA – Anti-bird Flu Drug for Human Clinical Trial Approved by China.

CHINA – China Plans 120 Billion Dollar Health Reform By 2011.

CHINA – 13 000 Fowl Culled in China After Bird flu.

CHINA – China-Russia Joint Research Center.

CHINA – Pig's Adult Stem Cells Produce Better Skins.

CHINA – More Health Scares Amid Slowdown, Warns China.

INDIA – Indian Experts Find Bacteria to Beat Global Heat.

INDIA – Two Indian Firms to set up Pre-clinical Trial Units in Malaysia.

JAPAN – Breakthrough in Universal Flu Vaccine Development.

SINGAPORE – Taiwan Pork Banned by AVA.

SINGAPORE – Stem-Cell Treatment For Joint Pain Gives New Hope.

SINGAPORE – Next Generation Healthcare Information System.

SINGAPORE – Top US University Sets up Research Centre in Singapore.

SINGAPORE – Increase in Life-saving Umbilical Cord Donations.

SINGAPORE – Singapore and China Scientists Report Breakthrough Research in Psoriasis.

SOUTH KOREA – Harmful Bacteria in French Baby Formula.

SOUTH KOREA – World's First Cloned Wolves to Test Reproductive Fitness.

TAIWAN – Genetic Testing on the Rise.

TAIWAN – Chinese Herbal Medicines Contain Western Drug Ingredients.

VIETNAM – Bird Flu Strikes in Five Provinces in Vietnam.

VIETNAM – Opening of Vietnam's First Stem Cell Bank, "MekoStem".

VIETNAM – Hanoi Suffers Worst Measles Outbreak in Decade.

OTHER REGIONS — EUROPE – Social Networking = Disease?

OTHER REGIONS — EUROPE – Cancer Morbidity 'to Double in 40 Years'.

OTHER REGIONS — NORTH AMERICA – Scientists Close in on 'Universal' Vaccine for Flu.

OTHER REGIONS — NORTH AMERICA – Hong Kong and US Scientists Develop New Bird Flu Vaccine.

AUSTRALIA – Australia Developing Breakthrough Leukemia Research Strategy.

AUSTRALIA – Obesity Associated With Detrimental Changes in Ovary.

AUSTRALIA – Queensland's Dengue Outbreak Worsens.

CHINA – Global Fund Assists Guangxi In Anti-AIDS Programs.

CHINA – Chinese Scientists Clone 5 Human Embryos for Research.

CHINA – China Stockpiles Vaccine for Possible Bird Flu Outbreak.

CHINA – QIAGEN Supports Cervical Cancer Screening for Underprivileged.

CHINA – JCI and Peking University Collaborate on Patient Safety and Education in China.

CHINA – Scientists Identify Key Drug Target in Bird Flu Virus.

CHINA – China Facing Burden from Chronic Diseases.

CHINA – Chinese Scientists Discover Achilles' Heel for SARS Virus.

CHINA – 18 HFMD Child Fatalities in China.

CHINA – Mainland China Reports 838 Infectious Disease Fatalities in February.

HONG KONG – Lethal Fungal Contamination in Drug.

HONG KONG – Hong Kong Experiences Record High HIV Infection Level.

INDIA – Stem Cells Help Save Man's Leg From Amputation.

INDIA – Human Trials for Kalaazar Vaccine Soon.

INDIA – Stem Cell Banks Expand on Prospects of Healthy Dividend.

INDIA – Biotech Rice to be Commercially Available in India by 2012.

INDIA – Rising Demand for Herbal Medicines in Jammu Kashmir.

INDIA – India, UNESCO to Set up Biotech Centre.

INDONESIA – Health Ministry Clears up Vaccine Dispute.

JAPAN – Bird Flu Detected in Second Quail Farm in Central Japan.

NEW ZEALAND – NZ Med Tech Sector Continues to Thrive.

NEW ZEALAND – Aerobics Classes can Cause Hearing Damage.

SINGAPORE – Dengue fever is on the rise in Singapore.

SINGAPORE – Will New US Policy Stem Talent Flow to Singapore?

SINGAPORE – HBOT Now Available at SGH.

SINGAPORE – Cancer Society's Colorectal Screenings Helped Save 123 lives.

SINGAPORE – National Heart Centre Singapore Unveils New Techniques for Heart Patients.

SINGAPORE – NTU Seals Global Partnerships in Environmental Sciences R&D.

SINGAPORE – NUH Cancer Center in Major Cancer Drug Trial.

SINGAPORE – Need More Trained Doctors? Build New Medical School.

VIETNAM – Harmful Bacteria Found in Bottled Water.

OTHER REGIONS — EUROPE – Hot Tea Linked to Throat Cancer.

USA – New Vaccine Method 'Offers Instant Immunity'.

AUSTRALIA – World-Class Cancer Center to be Built in Parkville.

AUSTRALIA – Cure Found for Devastating Muscle Disease.

AUSTRALIA – HIV Test to Help Monitor Sufferers.

AUSTRALIA – Radium Weed Weeds Out Sun Spots, Skin Cancer.

AUSTRALIA – Kava Safe and Effective in Reducing Anxiety.

CHINA – CAS Develops New Salt-tolerant Wheat.

CHINA – Search for Passengers on Flights with Flu Case.

HONG KONG – Hong Kong Confirms Asia's 1st Swine Flu Case.

INDIA – Indian Healthcare Market to Grow Despite Slowdown.

INDIA – WHO Lifts Vaccine Embargo on India.

JAPAN – Scientists Create World's First Transgenic Monkeys.

JAPAN – Japan Swine Flu Cases Surge.

NEW ZEALAND – New Frontiers in Gene Behavior.

NEW ZEALAND – Innovative Pet Food Research Consortium Launched.

SINGAPORE – 50 Receive Healthcare Humanity Awards.

SINGAPORE – No-Go for Swine Flu Parties.

SINGAPORE – Asia's First Combined Heart and Liver Transplant.

SINGAPORE – Singapore to Host Conference on Tobacco or Health.

SINGAPORE – Diabetes Hits Asia's Youth.

SOUTH KOREA – $14.6 mn for Fight Against New Flu.

TAIWAN – Flu Vaccine to be Available by End of Year.

TAIWAN – Mutation in Gene allows Cancer to Spread.

TAIWAN – Scientists Find Ways to Improve Cancer Drugs.

TAIWAN – Team Makes Discovery in Search for New Antibiotic.

TAIWAN – Taiwan Tags Sixteen Countries with Yellow Travel Alert Over Flu.

TAIWAN – Team Makes Breakthrough in Therapy for Childhood Cancer.

THAILAND – Thailand Tries to Become Starch-Production Hub.

THAILAND – Thailand and Taiwan to Begin Biotech Cooperation Plan.

VIETNAM – US gives Vietnam Protective Bird Flu Equipment.

OTHER REGIONS — UNITED STATES – Over 52's May Be Better Protected.

Situation of Chinese Medicine in China.

World's First Tetravalent Dengue Vaccine in Clinical Trial.

AUSTRALIA – US$6.5 Bn for Australia Science and Innovation.

AUSTRALIA – Genes Linked to Vitamin D Involved in Susceptibility to Multiple Sclerosis.

AUSTRALIA – Scientists Find Weak Link in Malaria Portal.

CHINA – China Makes First Pig Stem Cells.

CHINA – Genetic Tests to Unravel Prodigies.

INDIA – India Can Become a Global Pharma Innovation Hub.

INDIA – Anti-diarrhea Vaccine in Development.

JAPAN – Inevitable Public Debate over GM Primates.

NEW ZEALAND – NZ Biotech Industry Continues to Thrive.

SINGAPORE – 'Simulation Model' for Disease Spread.

SINGAPORE – Singapore's Challenge: Sustain Environment Long-Term.

SINGAPORE – Water Industry Players Partnering Education Sector.

SINGAPORE – World-Wide Debut For 16 Inventions.

TAIWAN – New Treatment for Uterine Fibroids.

TAIWAN – Taiwan to Develop Methods to Test Melamine Tableware.

TAIWAN – New Research Expected to Help Develop Universal Flu Vaccine.

VIETNAM – Herbal Capsules to Treat Womb Ulcers.

OTHER REGIONS — US – Baxter Could Have Pandemic Flu Vaccine in July.

OTHER REGIONS — US – Will US Dominate Biotech?

Novation, Cancer Therapeutics to Jointly Develop Cancer Therapies.

Mesoblast Announces Positive Results in Bone Marrow Transplant Trial.

Mingyuan Medicare Announces Collaboration on Major Infectious Diseases Detecting Platform.

DHL Launches first Life Science & Healthcare Competence Centre in Shanghai.

Abraxis Bioscience Launches ABRAXANE for Metastatic Breast Cancer.

GSK Enters Flu-Vax JV in China.

Biocon Launches Long Lasting Basal Insulin for Type 1 & Type 2 Diabetics.

Kemwell to build Biopharmaceutical Manufacturing Facility in India in Collaboration with Boehringer Ingelheim, Germany.

Hemispherx, Biken Expands Production Capacity for Swine Flu Vaccines.

D-SIMLAB Awarded S$500,000 Grant under SPRING Singapore's Technology.

GlaxoSmithKline Opens $600million Vaccine Plant.

Agilent Technologies Opens New Life Sciences Manufacturing Facility in Singapore.

Six Doctors Receive Clinician Scientist Awards.

AUSTRALIA – AIBN and US Researchers Join Forces.

AUSTRALIA – Harmless Gene Mutation Could Trigger Bowel Cancer.

AUSTRALIA – Australian Researchers Identify Melanoma Genes.

AUSTRALIA – UQ Generates First Australian Swine Flu Vaccine.

CHINA – Molecular Biologists Report New Immune Tolerance Mechanism.

CHINA – H1N1 Patients to Pay for their Own Treatment.

CHINA – China Begins Tests for First H1N1 Flu Vaccines.

INDIA – Stem Cells Could Regenerate Insulin-Secreting Tissues.

INDIA – Ayurveda Drug for Cancer.

INDIA – Global Medical Travel Industry To Grow 15-20% Annually.

JAPAN – Japanese Scientists Unveil Ultra-thin Surgical Patch.

SINGAPORE – US$10.4m Awarded to 8 Clean Energy Research Teams.

SINGAPORE – Strong Biomedical Sector Pulls Singapore Out of Recession.

SINGAPORE – Nanotechnology Combats Fatal Brain Infections.

SINGAPORE – Singapore Doctor Pioneers Concept of Biological Transplant for Bone Cancer.

VIETNAM – Cancer Tops List of Diseases Contracted in Vietnam.

OTHER REGIONS — NORTH AMERICA – U.S. Researchers Map Melon Genome.

OTHER REGIONS — EUROPE – Big Firms said to be Delaying Cheaper Drugs.

OTHER REGIONS — EUROPE – Humans can Give Swine Flu to Pigs.

Dow AgroSciences, NemGenix Establish New Collaboration in Plant Biotechnology Research.

A*STAR Scientists Discover 'FAIM' Function.

Thailand Develops Seed Viruses for H1N1 Vaccine Production.

AUSTRALIA – Australia's First Full Genome Project to be Conducted on Corals.

AUSTRALIA – Scientists May have Discovered New Potential Cure for Cancer.

AUSTRALIA – First Genetically-engineered Malaria Vaccine To Enter Human Trials.

CHINA – Lead Poisoning Sickens 600 Kids in China.

CHINA – Groundbreaking Treatment for Oxygen-deprived Newborns.

CHINA – China Builds First Heavy Ion Therapy Center for Cancer Patients.

CHINA – Creating Live Mice from Skin Cells.

INDIA – Human Clinical Trial in 2010 for Needle-free Measles Vaccination.

INDIA – Indian Wonder Herb can Treat Male Infertility.

JAPAN – Flood Resistant High-yield Rice Developed.

SINGAPORE – Minimally Invasive Option for Knee Cartilage Repair.

SINGAPORE – Novel Immunization Method for Malaria Offers Insights into Human Anti-Malaria Immune Response.

TAIWAN – Taiwan Researchers Identify Sites of Breast Cancer Genes.

TAIWAN – Taiwanese Researchers Develop Cell Therapy For Immunodeficiency.

TAIWAN – Remote Healthcare Services for High-risk Patients.

TAIWAN – Marine-derived Compounds Holds New Treatment Premise for Neuropathic Pain.

OTHER REGIONS — UNITED STATES – New No-needle Approach to Prevent Blood Clots.

University of Queensland and Life Technologies (LIFE) Collaborate on Landmark Cancer Research Studies in Australia.

Hexima Collaborates with Pioneer Hi-Bred in MGEV Research Licence.

Surpassing 50 Successful Implants for Miniaturized Heart Pump under Clinical Trial.

Pfizer in Partnership with Shanghai Institutes for Biological Sciences for Drug Discovery Activities.

Cryo-Cell Signs Exclusive Licensing Deal with Chinese Stem Cell Firm.

AlphaRx and Venturepharm Collaborate in Drug Development.

Sanofi Acquires Shantha Biotechnics.

Siemens Introduces Liver Elastography Technology in India.

A New Plant-based Antiviral for H1N1 Virus?

WebHeart^® in a Cardiovascular Study Solidifies New Force in Clinical Trials in Japan and Asia.

Astellas to Build Fermentation Tech Research Center.

A*STAR and Swiss Institute Collaborate to Boost Microfluidics Technology.

AUSTRALIA – Researchers Find Bacterium to Trip Malarial Mosquitoes.

AUSTRALIA – One Dose of H1N1 Vaccine May Provide Sufficient Protection for Infants and Children.

AUSTRALIA – Cosmetic Therapy Uses Patient's Own Plasma to Fix Wrinkles.

AUSTRALIA – Asthma Summer Warning.

AUSTRALIA – Link Between Sun Exposure and Food Allergies in Kids Revealed.

AUSTRALIA – Colon Simulator Reduces Cancer.

AUSTRALIA – Farmers Turn Organic for Personal Health.

AUSTRALIA – Rise in Dengue Cases Causes New Outbreak Fears.

CHINA – Western Corporations Move Key Offices to China.

CHINA – China Treating Severe Swine Flu with Blood Plasma.

CHINA – Traditional Medicine Beats H1N1 Virus.

CHINA – Sars Victims Suffer After-Effects.

CHINA – Higher Lung Cancer Risk in Eastern China.

CHINA – Experts Warn of Cancer Linked to Certain Herbs.

INDIA – CSIR Completes First Ever Human Genome Sequencing in India.

INDIA – India among Top 5 Government Funders of Neglected Diseases.

INDIA – Doctors Use Stem Cells to Regrow Teeth in Children.

INDIA – Delhi to Have First Govt-owned Liver Institute.

JAPAN – Israel, Japan Unite For First Time to Study Brain, Stem Cells.

PHILIPPINES – Stem Cell Therapy as Rejuvenation and Other Disease Treatment.

SINGAPORE – Scientists Discover Natural Compound in Palm Oil Kills Breast Cancer Cells.

SINGAPORE – More than 200 Scientists Attend A*STAR Biomedical Sciences Symposium.

SINGAPORE – Global Phase III Clinical Trial to Treat Head and Neck Cancer Begins.

EUROPE – Stem Cell Treatment Helps Regain Eyesight.

Australian Company Develops Potential UV Vaccine.

Phylogica Enters Agreement with Roche to Evaluate Phylomer Technology.

CSL Behring Awards $87,000 to Patient Organizations in USA.

Pfizer, Crown Bioscience Tie up for Asian Cancers R&D.

Sinovac Files Clinical Trial Application with SFDA for Vaccine against Hand, Foot, and Mouth Disease.

Takeda and Pfizer to Co-Promote Takeda's Actos^® (pioglitazone HCl) for the Treatment of Type 2 Diabetes in China.

Alvogen Launches Asia Operations.

Praj to Collaborate with Novozymes on Advanced Biofuels.

Biocon and HCG Group of Hospitals Join Hands to Fight Against Cervical Cancer.

Shantha Introduces India's First Oral Cholera Vaccine.

Pfizer, TCGLS to Develop Preclinical Candidate Molecules.

Hospira to Acquire Orchid's Generic Injectable Pharmaceuticals Business.

Dicerna Pharma, Kyowa Hakko to Collaborate on RNAi.

Ambit Biosciences and Astellas Enter Strategic Partnership.

Inno Biologics, CEVEC for Using Sign Agreement Human CAP Technology.

Patrys to Work with CSL to Explore Antibody Drugs.

Starpharma and Lilly Sign New Drug Delivery Collaboration for Human Pharmaceuticals.

Sanofi, Minsheng in China Consumer Health Venture.

Biocon Signs MoU with Malaysia's BiotechCorp.

Biocon, Bayer Tie up to Fight Diabetes in India.

Ranbaxy to Acquire Bangalore Based Biovel Life Sciences.

DiscoveRx, Jubilant Biosys Announce Agreement for Screening Services.

BD Biosciences Collaborates with ReaMetrix to Develop New, Affordable CD4 Testing Products to Help Fight HIV/AIDS in Developing Countries.

Aegis Therapeutics and Dr. Reddy's Announce Strategic Alliance.

Penwest Enters Into Research and Development Agreement with Otsuka Pharmaceutical.

AstraZeneca and CrystalGenomics Form Research Collaboration to Develop Novel Anti-Infective Treatments.

International and Local Recognition for Singaporean Biotech Start-up – Curiox Biosystems.

Roche Establishes New Medical Research Hub in Singapore.

Virbac Unveils First Regional R&D Center in Asia.