Narrow Results

Using in silico experiments, we isolate the effects of geometry on the efficiency of passive diffusion transport, P_S, of viral cargos to the nuclear region. We model the cell as an elliptical 2D structure (eccentricity e) containing a circular nucleus with radii R (semi-minor) and r, respectively. The cargos move in isotropic random walk inside the cell. P_S is estimated as the ratio of the number of cargos that reach the nuclear region and of cargos released. We show that P_S decreases with the total distance traveled but increases with r/R. Shifting the nuclear position inside circular cells (e = 0) produce probability distribution functions of total distance traveled that shifts to shorter modes as one side becomes closer to the cell membrane. On the contrary, cargos in more elongated cells (e = 0) have preserved P_S-values even for longer distances of travel inside the cell. Finally, an optimum r/R exists due to a trade-off between increased efficiency of transport to the nucleus and high cytoplasmic area. This work could contribute in elucidating the reason why some viruses induce asymmetry in their host cells.

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WuXi PharmaTech to Acquire AppTec Laboratory Services Inc.

Medtronic Expands in China.

Novelos Therapeutics and Lee's Pharmaceutical Sign Exclusive Collaboration Agreement.

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Merck Signs Global Multi-services Pact with HCL Tech.

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NasVax and SciGen Ltd to Develop and Market an Improved Hepatitis B Vaccine.

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AUSTRALIA – Sun Beds Killing 43 Aussies A Year.

CHINA – Chinese Skin Cream Recalled After Steroid Found.

CHINA – UN Urges China to Revamp Food Safety after Milk Crisis.

CHINA – Key Proteins Identified In the Quest for Male Contraceptive.

CHINA – Gene that May Contribute to Improved Rice Yield Identified.

CHINA – A New Institution to be Formed by Teaming up Biological Institutes in Beijing.

CHINA – Big Pharma Ranks China as No. 1 Destination in Asia for Pharmaceutical Outsourcing.

INDIA – Reliance Life Sciences Launches India's First Portal for Breast Cancer Genomics.

INDIA – New Health Scheme Launched in Kerala.

INDIA – Nobel Biocare Introduces New Dental Implant Program in India.

INDIA – Malaria Drug through Synthetic Biology.

JAPAN – Sleep Disorder Due to Genetic Mutation.

NEW ZEALAND – Crop and Food and Hortresearch to Merge.

SINGAPORE – NUS Researchers Create Antibody that may Eradicate Viral Diseases.

SINGAPORE – AMO Opens Eye-Care Training Center in Singapore.

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Pioneering application of Google Glass by Renji Hospital.

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