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The molecular biology of viruses can be effectively described by kinetic logic, even in its so-called “naïve” version, since feedback loops are implicated in all viral cycles and viral proteins generally display several functions. A general method for the evolution of systems involving feedback loops using this modelling is presented. It can be summarized as follows:

(i) description of the system through boolean equations,

(ii) identification of the steady states (is there a good agreement between the observations and the logical description?),

(iii) experimental determination of several parameters,

(iv) computer simulation of viral cycles,

(v) predictions and their relation to the biological facts.

This survey of oscillation between experimentation and logical description was applied to the study of rhabdovirus cycles and allowed us to describe some aspects of their gene expression.

This article summarizes the center for Molecular Medicine's research programs including regenerative medicine, immunology, virology, Singapore Oncogenome program, epithelial biology and genetic medicine.

Mab-Venture Biopharma & Thermo Fisher Establish Asia Pacific’s First “SmartFactory” for Antibody Drugs.

Venus Medtech’s TAVR Device Is Approved By CFDA, Creating A New Era of Interventional Cardiology in China.

Key Diabetes Receptor Structure Determined by International Collaboration.

China Sets Up National Lab Developing Brain-Like AI Technology.

Chinese Scientists Realize On-site Drug Detection.

Scientists Map Single-Copy HIV-1 Provirus Loci in Human Chromosomes in Live Host Cells.

Gene Variant Explains Differences in Blood Fatty Acid Levels.

Scientists Illustrate How Host Cell Responds to Zika Virus Infection.

Hong Kong News – Uni-Bio Science Launches Best-in-Class Oral Anti-Diabetic Drug Mitiglinide Branded “博康泰^®”(Bokangtai).

The following topics are under this section:

• ASIA-PACIFIC — Collaborative research effort reveals chemical compound that kills drug-resistant bacteria
• ASIA-PACIFIC — Big Data Analytics used for Personalized Assessment Tool for Cancer Diagnosis
• ASIA-PACIFIC — Identifying the Molecular Mechanisms of Creating a Memory
• ASIA-PACIFIC — Funding for New Stem Cell Research provides Hope for Premature Born Babies
• ASIA-PACIFIC — Human Cortical Organoids used to Identify Mechanisms behind Epilepsy in Angelman Syndrome
• ASIA-PACIFIC — The Future of Contact Lenses: Self-Moisturising Technology
• ASIA-PACIFIC — Glycosylation of Protein Structure on Virus provide Insight to Molecular Understanding
• ASIA-PACIFIC — Comprehensive Mapping of the Human Brain using Synchrotron X-rays
• REST OF THE WORLD — Uncovering New Tricks for Old Drugs
• REST OF THE WORLD — Combination of Prenatal Smoking and Drinking adds on to Risk of SIDS
• REST OF THE WORLD — Blood Pressure Readings Could Provide Valuable Information on Early Warning Signs of Heart Disease
• REST OF THE WORLD — Study finds Households in the United States Wastes nearly a Third of the Food they Buy

The following topics are under this section:

• 10 minutes to screen 4,000 drugs
• Remdesivir: Humanity’s hope against COVID-19?
• Epidemiology of COVID-19 and Perspectives from Chinese Medicine
• Tiding of the Outbreak

The following topics are under this section:

• Providing New Insights to Fighting COVID-19 with AI-Powered Remote Monitoring Platform
• Agreement Signed for Production of Anti-VISTA Antibody for Cancer Clinical Trial
• Exploring the Cancer Genomic Landscape of the Japanese Population
• First Center of Excellence in Singapore to Advance Imaging Mass Cytometry
• RMAT Designation Granted by FDA using CAR-T Cell Therapy for CD-30 Positive Classical Hodgkin Lymphoma
• Expanding Investment for COVID-19 Vaccine Development
• Singapore-based Biotechnology Company Launches Integrated Agri-Food Pilot Facility

The following topics are under this section:

• COVID-19 and its Impact on a Global and Societal Scale
• Possible, Immediate Solution for COVID-19: A position paper
• Surviving COVID-19
• Fundamentals to Help Hospitals in ASEAN stay Resilient

For the month of September 2020, APBN dives into the world of 3D printing and its wide range of real-world applications. Keeping our focus on the topic of the year, the COVID-19 pandemic, we explore the environmental impact of the global outbreak as well as gain insight to the top 5 vaccine platforms used in vaccine development. Discover more about technological advancements and how it is assisting innovation in geriatric health screening.

For the month of October 2020, our editorial theme focuses on artificial intelligence technologies. An overview of how artificial intelligence is helping in the fight against the COVID-19 pandemic is covered by an article contribution in the Features section. Discover how artificial intelligence is enhancing the drug discovery process. In the Spotlights section, explore new research and discoveries on one of our vital organs, the Heart. Gain insights to what it takes to develop a COVID-19 vaccine during this pandemic.

For the month of December 2020, APBN features article contribution from variety of writers. In the Features we take a dive into how COVID-19 vaccines could be shipped worldwide in an article by Kawal Preet, President of Asia Pacific, Middle East and Africa (AMEA) region for FedEx. For the Columns section, explore the transformations in telehealth and telemedicine in the Asia Pacific region. Also, writers from ACT Genomics discuss how liquid biopsy could provide potential in replacing tissue biopsy in genomic alteration profiling. For this month in the Spotlights, are highlights from the recent APACMed Virtual Forum 2020 on how technology is changing the landscape of healthcare. Finally, Professor Nadey Hakim, a general surgeon and currently the vice president of the Royal Society of Medicine weighs in on the recent release of data on the study for Sputnik V vaccine against COVID-19.

For the months of November and December 2022, APBN explores the theme of ''Virology'' and considers the role they play in our environment and how we can deal with them in the years to come.

Firstly, we dive into the world of marine viruses with Vanessa Lunardi as she shares with us how these microscopic agents direct life in the ocean and how they could potentially contribute to climate change.

Next, Dr Sunny Himansu, Associate Director of Infectious Diseases at Moderna, talks about the Nipah virus, its presence in Southeast Asia, and how Moderna is working to develop a Nipah virus mRNA vaccine.

Closer to home, Junghun Justin Kim, Country Manager at Takeda Singapore, discusses the issue of dengue – a disease that has seen a three-fold increase in Singapore this year – and how we can best manage it.

Other highlights in this issue include a column by Ivor Campbell, CEO of Snedden Campbell, on the various developments in diagnostics and medical technology as a result of the COVID-19 pandemic, and an interview with Erica Wu Yun, Nurse Clinician at Allium Care Suites on how we can best prepare for a transition from life to death.

The author presents theoretical mean-field analysis of the initial phase of the kinetics of intracellular replication of plus-stranded RNA viruses, which are abundant and include, e.g., the hepatitis C virus (HCV). The treatment is based on the conventional concept that the replication process of such viruses takes place at the membrane complexes formed with participation of viral proteins, e.g., NS5A in the HCV case. The key novel prediction supported by Monte Carlo calculations is that this scheme may be insufficient in order to describe the very initial phase of the process, because the initial intracellular viral RNA and protein populations may in this case go extinct rather than overcome the kinetic barrier for transition to the full-scale infection of a host cell. Practically, this means that in such situations, the conventional replication scenario should be complemented by another pathway, e.g., by replication outside the membrane without viral proteins, which operates in the very beginning.