In the recent years, nanotechnologies have been widely used in several fields regarding their rapid developments which creates a lot of prospects for researchers and engineers. More specifically, replacement of conventional liquids with nanoliquids is considered as an innovative solution to heat transfer problems. Keeping the aforesaid pragmatism of nanofluid in view, we have considered a time-dependent mathematical model to formulate the heat sink–source-based Sutterby liquid under thermophoretic and Brownian movements with wedge geometry. Additionally, convective condition, heat sink/source and chemical reaction properties are considered. Appropriate similarity transformations are used to obtain ordinary differential equations (ODEs) from the corresponding PDEs. Furthermore, coupled ODEs are tackled numerically by technique bvp4c in MATLAB. Discussion for thermal and concentration distribution is also presented graphically. Moreover, the temperature field enhance for Brownian parameter and decays for concentration field in this study. A similar impact has been examined for unsteadiness and chemical reaction parameters on concentration plot. Thermal distribution declines for boosted Prandtl number.