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Studying the topological aspects of M-branes in M-theory leads to various structures related to Wu classes. First we interpret Wu classes themselves as twisted classes and then define twisted notions of Wu structures. These generalize many known structures, including Pin- structures, twisted Spin structures in the sense of Distler–Freed–Moore, Wu-twisted differential cocycles appearing in the work of Belov–Moore, as well as ones introduced by the author, such as twisted Membrane and twisted Stringc structures. In addition, we introduce Wuc structures, which generalize Pinc structures, as well as their twisted versions. We show how these structures generalize and encode the usual structures defined via Stiefel–Whitney classes.