In this study, in order to obtain the optimal fabricating condition, the influences of heating temperature and time on the fabrication of zinc oxide (ZnO) nanowires are clarified. During this process, the synthesis and scanning electron microscope (SEM) images of ZnO nanostructures, produced by direct heating of metallic zinc, are presented. Besides, the SEM images and X-ray diffraction (XRD) patterns of products under different conditions are compared to analyze the surface morphology and composition of products. In the final observation, the best diameters of ZnO nanowires are achieved as 60–70 nm, which can be successfully applied as a substrate in Raman measurement. The optimal temperature is 450∘C, as well as the optimal time is 40–50 min.