International Journal of Neural Systems

The cerebellum, which is responsible for motor control and learning, has been suggested to act as a Smith predictor for compensation of time-delays by means of internal forward models. However, insights about how forward model predictions are integrated in the Smith predictor have not yet been unveiled. To fill this gap, a novel bio-inspired modular control architecture that merges a recurrent cerebellar-like loop for adaptive control and a Smith predictor controller is proposed. The goal is to provide accurate anticipatory corrections to the generation of the motor commands in spite of sensory delays and to validate the robustness of the proposed control method to input and physical dynamic changes. The outcome of the proposed architecture with other two control schemes that do not include the Smith control strategy or the cerebellar-like corrections are compared. The results obtained on four sets of experiments confirm that the cerebellum-like circuit provides more effective corrections when only the Smith strategy is adopted and that minor tuning in the parameters, fast adaptation and reproducible configuration are enabled.

We employed high-density microelectrode arrays to investigate spontaneous firing patterns of neurons in brain circuits of the primary somatosensory cortex (S1) in mice. We recorded from over 150 neurons for 10min in each of eight different experiments, identified their location in S1, sorted their action potentials (spikes), and computed their power spectra and inter-spike interval (ISI) statistics. Of all persistently active neurons, 92% fired with a single dominant frequency — regularly firing neurons (RNs) — from 1 to 8Hz while 8% fired in burst with two dominant frequencies — bursting neurons (BNs) — corresponding to the inter-burst (2–6Hz) and intra-burst intervals (20–160Hz). RNs were predominantly located in layers 2/3 and 5/6 while BNs localized to layers 4 and 5. Across neurons, the standard deviation of ISI was a power law of its mean, a property known as fluctuation scaling, with a power law exponent of 1 for RNs and 1.25 for BNs. The power law implies that firing and bursting patterns are scale invariant: the firing pattern of a given RN or BN resembles that of another RN or BN, respectively, after a time contraction or dilation. An explanation for this scale invariance is discussed in the context of previous computational studies as well as its potential role in information processing.

Fatigue is one problem with driving as it can lead to difficulties with sustaining attention, behavioral lapses, and a tendency to ignore vital information or operations. In this research, we explore multimodal physiological phenomena in response to driving fatigue through simultaneous functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG) recordings with the aim of investigating the relationships between hemodynamic and electrical features and driving performance. Sixteen subjects participated in an event-related lane-deviation driving task while measuring their brain dynamics through fNIRS and EEGs. Three performance groups, classified as Optimal, Suboptimal, and Poor, were defined for comparison. From our analysis, we find that tonic variations occur before a deviation, and phasic variations occur afterward. The tonic results show an increased concentration of oxygenated hemoglobin (HbO₂) and power changes in the EEG theta, alpha, and beta bands. Both dynamics are significantly correlated with deteriorated driving performance. The phasic EEG results demonstrate event-related desynchronization associated with the onset of steering vehicle in all power bands. The concentration of phasic HbO₂ decreased as performance worsened. Further, the negative correlations between tonic EEG delta and alpha power and HbO₂ oscillations suggest that activations in HbO₂ are related to mental fatigue. In summary, combined hemodynamic and electrodynamic activities can provide complete knowledge of the brain’s responses as evidence of state changes during fatigue driving.

Working memory (WM) is a crucial cognitive process and its disruption is among the earliest symptoms of Alzheimer’s disease. While alterations of the neuronal processes underlying WM have been evidenced in mild cognitive impairment (MCI), scarce literature is available in subjective cognitive decline (SCD). We used magnetoencephalography during a WM task performed by MCI $(n=45)$, SCD $(n=49)$ and healthy elders $(n=49)$ to examine group differences during the maintenance period (0–4000ms). Data were analyzed using time–frequency analysis and significant oscillatory differences were localized at the source level. Our results indicated significant differences between groups, mainly during the early maintenance (250–1250ms) in the theta, alpha and beta bands and in the late maintenance (2750–3750ms) in the theta band. MCI showed lower local synchronization in fronto-temporal cortical regions in the early theta–alpha window relative to controls $(p=2\times 10^{-03})$ and SCD $(p=4\times 10^{-03})$, and in the late theta window relative to controls $(p=1\times 10^{03})$ and SCD $(p=0.01)$. Early theta–alpha power was significantly correlated with memory scores $(\mathrm{\text{rho}}=0.24,p=0.02)$ and late theta power was correlated with task performance $(\mathrm{\text{rho}}=0.24,p=0.03)$ and functional activity scores $(\mathrm{\text{rho}}=-0.23,p=0.02)$. In the early beta window, MCI showed reduced power in temporo-posterior regions relative to controls $(p=3\times 10^{-03})$ and SCD $(p=0.02)$. Our results may suggest that these alterations would reflect that memory-related networks are damaged.

Epileptic seizures arise from synchronous firing of multiple spatially separated neural masses; therefore, many synchrony measures are used for seizure detection and characterization. However, synchrony measures reflect only the overall interaction strength among populations of neurons but cannot reveal the coupling strengths among individual populations, which is more important for seizure control. The concepts of reachability and reachable cluster were proposed to denote the coupling strengths of a set of neural masses. Here, we describe a seizure control method based on coupling strengths using combination convolutional neural network (CCNN) modeling. The neurophysiologically based neural mass model (NMM), which can bridge signal processing and neurophysiology, was used to simulate the proposed controller. Although the adjacency matrix and reachability matrix could not be identified perfectly, the vast majority of adjacency values were identified, reaching 95.64% using the CCNN with an optimal threshold. For cases of discrete and continuous coupling strengths, the proposed controller maintained the average reachable cluster strengths at about 0.1, indicating effective seizure control.

Human gait recognition is one of the most promising biometric technologies, especially for unobtrusive video surveillance and human identification from a distance. Aiming at improving recognition rate, in this paper we study gait recognition using deep learning and propose a novel method based on convolutional Long Short-Term Memory (Conv-LSTM). First, we present a variation of Gait Energy Images, i.e. frame-by-frame GEI (ff-GEI), to expand the volume of available Gait Energy Images (GEI) data and relax the constraints of gait cycle segmentation required by existing gait recognition methods. Second, we demonstrate the effectiveness of ff-GEI by analyzing the cross-covariance of one person’s gait data. Then, making use of the temporality of our human gait, we design a novel gait recognition model using Conv-LSTM. Finally, the proposed method is evaluated extensively based on the CASIA Dataset B for cross-view gait recognition, furthermore the OU-ISIR Large Population Dataset is employed to verify its generalization ability. Our experimental results show that the proposed method outperforms other algorithms based on these two datasets. The results indicate that the proposed ff-GEI model using Conv-LSTM, coupled with the new gait representation, can effectively solve the problems related to cross-view gait recognition.