"Research on immunity has dramatically expanded in recent six decades, yielding exciting new information concerning the molecules and cells that initiate the multi-faceted processes combined under the term 'Molecular Immunity'. These processes are crucial for protection against invaders, but are also responsible for certain pathogenic conditions. Prof. Kendall Smith, a prominent contributor to this field, provides in this book, for the first time, the detailed history of thoughts and consequent achievements in the field of cellular immunology."
Dr Igal Gery
Scientist Emeritus
National Eye Institute, NIH
This book covers a scientific history of the discoveries in immunology of the past 60-years, i.e. what was discovered, who made the advances and how they accomplished them, and why others did not.
All molecular advances occurred in the last 60 years, and no one has described them.
Sample Chapter(s)
Prologue
1: Twenty Years of Cellular Discovery
Contents:
- Twenty Years of Cellular Discovery
- From Activities to Molecules: The Interleukins
- The Beginnings of Molecular Immunology
- Molecular Mechanisms of T Cell Cytolysis
- Molecular Mechanisms of T Cell "Help"
- The Molecules of Macrophages
- Additional T Cell signals: Co-stimulatory and Co-inhibitory
- Regulatory T Cells
- Immunotherapy
Readership: Undergraduates, graduate students and academics in medicine (immunology) and life sciences (molecular biology, genetics).
"It is an account by an expert who personally participated and contributed to the crucial immunological discoveries, that is directed at expert immunologists. The book undoubtedly will be a rich source of historical information concerning the critical hypotheses and experimental discoveries over the past century that are now beginning to lead to successful immunotherapy of diverse conditions ranging from autoimmunity to cancer."
Joost J Oppenheim
National Cancer Institute, USA
"This informative and detailed book from a pioneer in immunology develops themes based in both the history of the subject, and in an understanding of contemporary mechanisms, that provide unique insights into this complex and medically important area of science."
Dr Peter C Doherty
Department of Microbiology and Immunology
University of Melbourne at the Doherty Institute, Australia
"Research on immunity has dramatically expanded in recent six decades, yielding exciting new information concerning the molecules and cells that initiate the multi-faceted processes combined under the term 'Molecular Immunity'. These processes are crucial for protection against invaders, but are also responsible for certain pathogenic conditions. Prof. Kendall Smith, a prominent contributor to this field, provides in this book, for the first time, the detailed history of thoughts and consequent achievements in the field of cellular immunology."
Dr Igal Gery
Scientist Emeritus
National Eye Institute, NIH