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The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development.
Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.
Sample Chapter(s)
Chapter 1: MIF, MIF Alleles, and the Regulation of the Host Response (486 KB)
Contents:
- MIF Structure and Mechanism of Action:
- MIF, MIF Alleles, and the Regulation of the Host Response (Richard Bucala)
- MIF and the Chemokine Axis (Sandra Kraemer, Christian Weber and Jürgen Bernhagen)
- CD74, the Natural Receptor for MIF, Regulates Cell Survival in Health and Disease (Idit Shachar, Maya Gordin, Sivan Cohen, Inbal Binsky, Ayelet Marom and Shirly Becker-Herman)
- Towards the MIF Interactome (Jörg Klug and Andreas Meinhardt)
- Structural Studies of Small Molecule Inhibitors of MIF (Yoonsang Cho and Elias J Lolis)
- Regulation of MIF Expression:
- Epigenetic Control of MIF Expression (Thierry Roger, Jérôme Lugrin, Xavier C Ding and Thierry Calandra)
- Regulation of MIF Gene Expression in the Lung (Lili Li and John Baugh)
- Hypoxic Adaptation Facilitated by MIF (Robert A Mitchell)
- Infectious and Inflammatory Diseases:
- MIF in Infectious Diseases (Marcelo Torres Bozza and Claudia Neto Paiva)
- Role of Macrophage Migration Inhibitory Factor (MIF) in Parasitic Diseases (Rashmi Tuladhar, Ran Dong, Sanjay Varikuti, John R David and Abhay R Satoskar)
- MIF and Pulmonary Disease (Gordon Cooke, Michelle E Armstrong, Helen Conroyand Seamas C Donnelly)
- The Role of MIF in Neurogenic Inflammation (Pedro L Vera and Katherine L Meyer-Siegler)
- MIF and Lower Urinary Tract Disorders (Anthony DeAngelis, Phillip P Smith and George A Kuchel)
- Neoplasia:
- MIF in the Pathogenesis of Urological Cancer (Katherine L Meyer-Siegler and Pedro L Vera)
- MIF in Ovarian Cancer: Detection and Treatment (Guy Nadel, Ayesha B Alvero and Gil Mor)
- The Role of MIF on Tumorigenicity of Embryonic Stem Cells (Yi Ren)
- Atherogenesis and Cardiovascular Disease:
- MIF in Atherosclerosis (Heidi Noels, Jürgen Bernhagen and Christian Weber)
- MIF in Cardiovascular Disease (Edward J Miller, Dake Qi, Ji Li and Lawrence H Young)
- Neurophysiology and Neuropathology:
- A Detrimental Role of MIF in Ischemic Brain Damage (Kate L Lambertsen and Tomas Deierborg)
- Association of MIF with Autism Spectrum Disorders (Ivana Kawikova, James F Leckman, Astrid Morer and Elena L Grigorenko)
Readership: Basic scientists working in inflammation and immunity as well as cytokine biology; clinically oriented scientists in infectious diseases, clinical immunology, and rheumatology; pharmacologists; drug development groups.
