Resveratrol is a structurally simple, grape-derived polyphenol with seemingly boundless biological activities. The Editors have assembled a group of renowned scientists who have illustrious careers and lifelong passions for studies of this compound. Each chapter covers topics using published and, at times, unpublished data to provide scholarly and comprehensive reviews and perspectives. Several areas with basic clinical and public health interests are highlighted. The book is intended to serve as a text and reference covering recent research findings and clinical applications in the field.
The content is presented in several parts: mechanistic leads provided by laboratory studies of resveratrol; cellular and molecular targets of resveratrol; modulation of disease states by resveratrol; virtual leads and drug discovery.
Sample Chapter(s)
Preface
Chapter 1: Unraveling and Trailblazing Cardioprotection by Resveratrol
Contents:
- Unraveling and Trailblazing Cardioprotection by Resveratrol (Tze-chen Hsieh and Joseph M Wu)
- Interrogating and Mining Mechanisms and Targets of Chemoprevention by Resveratrol (Tze-chen Hsieh, Barbara B Doonan and Joseph M Wu)
- Resveratrol as an Activator or Inhibitor of Enzymes and Proteins (Avinash Kumar, Eun-Jung Park and John M Pezzuto)
- Roles of Resveratrol as Signaling Sensor and Gatekeeper (Ya-Jung Shih, Yi-Ru Chen, Kuan Wang, Jacqueline Whang-Peng, Heng-Yuan Tang, Hung-Yun Lin and Paul J Davis)
- Control of AKT Survival Kinase Activation/Function by Resveratrol and Its Target Protein NQO2 (Tze-chen Hsieh and Joseph M Wu)
- The Effects of Resveratrol and Its Analogues on the Sirt5-GLS Axis-Mediated Glutamine Metabolic Reprogramming in Cancer Cells (Tze-chen Hsieh, Jaysen Zhang, Dylan J Bennett, John M Pezzuto, Mark Cushman and Joseph M Wu)
- Resveratrol and Cancer Cell Biology (Chandra K Singh, Gagan Chhabra and Nihal Ahmad)
- A Link Between Immunity and Inflammation: Actionable Targets of Resveratrol (Dominique Delmas, Emeric Limagne, Anne Vejux, François Ghiringhelli and Virginie Aires)
- Resveratrol: A Therapeutic Tool Against Age Related Lung Diseases (Cecilia G Sanchez)
- Resveratrol and Aging (Sergio D Paredes, Lisa Rancan, M Cruz García, Elena Vara and Jesús A F Tresguerres)
- Resveratrol and Advancing Virtual Drug Discovery (Amanda H Pham, Mark Phillips and Zhong-Ru Xie)
- Evolution from Gene to Gene Network: Using Bioinformatics to Gain Insights into the Chemopreventive Mechanism of Resveratrol (Evelien Schaafsma, John T Pinto, Joseph Garvey, Radha Garvey, Joseph M Wu and Tze-chen Hsieh)
Readership: Resveratrol researchers, nutritional scientists, healthcare professionals, integrative medicine professionals, government regulatory agencies, biotech and pharmaceutical companies, patients interested in using resveratrol to manage a variety of diseases.
Joseph M Wu, PhD, Professor, New York Medical College.
Professor Wu received his BS (Honors) from McGill University in 1970, majoring in Biochemistry. He obtained his MS in Chemistry in 1972 and Biological Sciences in 1975, both from Florida State University. Following a two-year post-doctoral training in Biochemistry at Temple University, Dr Wu became a faculty member at the New York Medical College where he currently holds the rank of Professor of Biochemistry and Molecular Biology and is also a member of the Brander Cancer Research Institute.
Professor Wu is a biochemist/cell-molecular biologist with a long history of research on mechanism of gene regulation and expression in cancer and other chronic diseases. At the New York Medical College, Dr Wu has trained 11 PhD and 65 MS students. He has authored 228 peer-reviewed scientific articles and reviews, and 21 book chapters and 139 abstracts. Since 1994, Dr Wu has been studying the mechanism of action of resveratrol, retinoids, phytochemicals, and proprietary herbal formulations, in the context of chemoprevention and cardioprotection.
Tze-chen Hsieh, PhD, Research Associate Professor, New York Medical College.
Dr Hsieh is a Research Associate Professor in the Department of Biochemistry and Molecular Biology at New York Medical College. She is also a member of the Brander Cancer Research Institute at the same institution. Dr Hsieh earned her BS in National Chung Shing University in 1984 and received her MS and PhD at Texas Tech University in 1988 and 1992. She started her training in the Department of Medicine at New York Medical College as a postdoctoral fellow in 1992. She joined the Department of Biochemistry and Molecular Biology as a Research Associate in 1994, and was promoted to the rank of Research Assistant Professor in 1997 and her current position in 2009.
Dr Hsieh has been studying mechanism of cell proliferation, differentiation, and induction of apoptosis for the past ten years using prostate cancer as a model. She has authored 121 peer-reviewed scientific articles, 9 book chapters, 53 abstracts and has given 13 invited presentations since 1992. Although trained as a cell biologist, Dr Hsieh has devoted a considerable amount of time and effort in learning and mastering the principles and applications of biochemical and molecular approaches in recent years and has applied this knowledge base to her personal interest on studies of prostate cancer, particularly in the area of control of the tumor by resveratrol.