Narrow Results

With the first detection of gravitational waves expected in the next decade, increasing efforts are made toward the electromagnetic follow-up observations of gravitational wave events. In this paper, I discuss the prospect of real-time detection and source localization for gravitational waves from neutron star–neutron star binary or neutron star–black hole binary coalescences before their merger. I show that several low-latency search pipelines are already under intensive development with the aim to provide real-time detections of these events. There will also be fast responding and/or wide-field electromagnetic telescopes available to help catch the electromagnetic or particle flashes possibly occurring during or immediately after their merger. It has been shown that a few coalescence events per year can be detected by advanced LIGO-VIRGO detector network tens of seconds before their merger. However, most of these events will have poor sky direction localization for the existing gravitational-wave detector network, making it extremely challenging for follow up observations by astronomical telescopes aiming at catching events around the merger time. A larger detector network including the planned detectors in Japan and in India will play an important role in improving the angular resolution and making prompt follow up observations much more realistic. A new detector at the Southern Hemisphere AIGO will further contribute significantly to this aspect.

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The use of microfluidics has become widespread in recent years because of the use of lesser resources such as small size, low volume of reagents, and physiological representation of mammalian cells. One of the advantages of microfluidic-based cell culture is the ability to perfuse culture media which tends to improve cellular health and function. Although measurement of cellular function conventionally is carried out using well-plates and plate readers, these approaches are insufficient to carry out in-line analysis of perfused cell cultures because of mismatch between volumes and sensitivity. We report the development of a novel microfluidic device and assay that is carried out under perfusion, in-line to measure the cholesterol secreted from a human hepatocyte tissue-chip. The heart of the assay is the unique implementation of enzymatic chemistry that is carried out on a polystyrene bead. Using this approach, we successfully measured cholesterol secreted by the perfused human hepatocytes.