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Chrysanthemum indicum L.: A Comprehensive Review of its Botany, Phytochemistry and Pharmacology

Yanhao Shao

School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530200, P. R. China

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Yunda Sun

School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530200, P. R. China

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Ding Li

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China

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, and

Yiping Chen

School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530200, P. R. China

Guangxi Key Laboratory of Translational Medicine for Treating High-Incidence Infectious Diseases with Integrative Medicine, Nanning 530200, P. R. China

E-mail Address: yipchen2009@foxmail.com

Correspondence to: Dr. Yiping Chen, School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, 13 Xianhu Avenue, Qingxiu District, Nanning 530200, P. R. China. Tel: (+86) 771-473-3943, Fax: (+86) 771-495-3042

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https://doi.org/10.1142/S0192415X20500421Cited by:72 (Source: Crossref)

Abstract

Chrysanthemum indicum L. (C. indicum L.), a member of the Compositae family, is a perennial plant that has been used as a traditional medicine for more than 2000 years in China and is widely used for the treatment of Pemphigus, swelling, pain, and scrofula. To date, more than 190 chemical constituents have been isolated and identified from this plant, including flavonoids, terpenoids, phenylpropanoids, and phenolic acids. Numerous modern studies have shown that extracts or monomeric compounds from C. indicum L. have several pharmacological activities, such as anti-inflammatory anti-oxidation, antipathogenic microorganism, anticancer, immune regulation, and hepatoprotective effects. However, resource availability, the research on the mechanism, and quality control are still insufficient, which deserves further efforts. In this paper, the advances in botany, phytochemistry, and pharmacology of C. indicum L were reviewed. We hope that this review can provide important information for traditional Chinese medicine, phytochemistry, synthetic and medicinal chemistry researchers for making full use of C. indicum L. resource.

Keywords:

References

Afanas’ev, I.B., A.I. Dcrozhko, A.V. Brodskii, V.A. Kostyuk and A.I. Potapovitch . Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem. Pharmacol. 38: 1763–1769, 1989. Medline, Web of Science, Google Scholar
Ahmad, E.S., S. Girgis, T.M. Shoman, A.E. El-Din and M.M. Hassanane . Impact of Chrysanthemum indicum on genotoxicity and hepatic and kidney function in anticancer drug adriamycin exposed mice. Adv. Environ. Biol. 9: 232–236, 2015. Google Scholar
Amrani, A., O. Benaissa, N. Boubekri, K. Biod, R. Djabari, N. Beroal, D. Zama, F. Benayache and S. Benayache . Impact of Chrysanthemum fontanesii extract on sodium valproate mediated oxidative damage in mice kidney. J. Appl. Pharm. Sci. 6: 67–71, 2016. Google Scholar
Arokiyaraj, S., M.V. Arasu, S. Vincent, N.U. Prakash, S.H. Choi, Y.K. Oh, K.C. Choi and K.H. Kim . Rapid green synthesis of silver nanoparticles from Chrysanthemum indicum L. and its antibacterial and cytotoxic effects: An in vitro study. Int. J. Nanomed. 9: 379–388, 2014. Medline, Web of Science, Google Scholar
Arokiyaraj, S., V.D. Kumar, V. Elakya, T. Kamala, S.K. Park, M. Ragam, M. Saravanan, M. Bououdina, M.V. Arasu and K. Kovendan . Biosynthesized silver nanoparticles using floral extract of Chrysanthemum indicum L.—potential for malaria vector control. Environ. Sci. Pollut. R. 22: 9759–9765, 2015. Medline, Web of Science, Google Scholar
Bai, S.Y. and J. Lan . Contents compare of Flavonoids in different parts of Chrysanthemum indicum L. Qilu Pharm. Affair. 24: 355–356, 2005. Google Scholar
Bai, L., X. Li, L. He, Y. Zheng, H. Lu, J. Li, L. Zhong, R. Tong, Z. Jiang and J. Shi . Antidiabetic potential of flavonoids from traditional Chinese medicine: A review. Am. J. Chin. Med. 47: 933–957, 2019. Link, Web of Science, Google Scholar
Chatterjee, A., S. Sarkar and S.K. Saha . Acacetin 7-O- $β$ -d-galactopyranoside from Chrysanthemum indicum. Phytochemistry 20: 1760–1761, 1981. Web of Science, Google Scholar
Chen, J.H. and C.T. Ho . Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds. J. Agr. Food Chem. 45: 2374–2378, 1997. Web of Science, Google Scholar
Chen, W.J. Studies on the chemical constituents of flos Chrysanthemum indicum L. and extraction process of total flavonoids. Shandong University of Traditional Chinese Medicine, 2009. Google Scholar
Chen, Y.Y. Studies on the anti-HBV activity constituents from the Chrysanthemum indicum L. Guangxi University of Chinese Medicine, 2012. Google Scholar
Chen, C.Y., C. Deng, Y.L. Zhao and Z.Z. Han . Textual research on medicine origin of wild Chrysanthemum. J. Hunan Univ. Chinese Med. 35: 69–72, 2015. Medline, Web of Science, Google Scholar
Chen, J., X. Yang, B. Li, K. Yang, Y. Wang, K. Sun, Y. Zhang and W. Zhu . A new sesquiterpenoid from Chrysanthemum indicum. Chem. Nat. Compd. 55: 1076–1079, 2019. Web of Science, Google Scholar
Cheng, W., J. Li, T. You and C. Hu . Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linne. J. Ethnopharmacol. 101: 334–337, 2005a. Medline, Web of Science, Google Scholar
Cheng, W.M., T.P. You and L.I. Jun . A new compound from the bud of Chrysanthemum indicum L. Chinese Chem. Lett. 16: 1341–1342, 2005b. Web of Science, Google Scholar
Cheon, M.S., T.S. Yoon, D.Y. Lee, G.Y. Choi, B.C. Moon, A. Lee, B.K. Choo and H.K. Kim . Chrysanthemum indicum Linné extract inhibits the inflammatory response by suppressing NF- $κ$ B and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages. J. Ethnopharmacol. 122: 473–477, 2009. Medline, Web of Science, Google Scholar
Chien, M.K., Z.X. Chen and K.F. Tseng . Studies on the constituents of ye-ju-hua, the flower of Chrysanthemum indicum L.(II) The structure of Yuhua lactone. Acta Pharm. Sin. 10: 129–134, 1963. Google Scholar
Commission, C.P. , Pharmacopoeia of the People’s Republic of China, Vol. 1. China Medical Science and Technology Press, Beijing, China, 2015. Google Scholar
Dai, G.W. Clinical observation of Chrysanthemum indicum preparations — Therapeutic effect analysis of 454 cases. China J. Chinese Mater. Med. 8: 39–40, 1983. Google Scholar
Dai, S. Isolation, identification and analysis of hepatoprotective constituents from Chrysanthemum indicum L. Anhui Medical University, 2013. Google Scholar
Deng, Q.Y. and Z.X. Feng . A new sesquiterpene from Chrysanthemum indicum. Chinese Chem. Lett. 4: 893–894, 1993. Google Scholar
Dixon, R.A. and G.M. Pasinetti . Flavonoids and isoflavonoids: From plant biology to agriculture and neuroscience. Plant Physiol. 154: 453–457, 2010. Medline, Web of Science, Google Scholar
Dong, M., D. Yu, V. Duraipandiyan and A.-D.N. Abdullah . The protective effect of Chrysanthemum indicum extract against ankylosing spondylitis in mouse models. BioMed. Res. Int. 2017: 8206281–8206287, 2017. Medline, Web of Science, Google Scholar
Feng, Z.M. Studies on the chemical constituents and bioactivites of Chrysanthemum indicum L. Chinese Academy of Medical Sciences, Peking Union Medical College, 2009. Google Scholar
Feng, Z.M., Y.N. Yang, J.S. Jiang and P.C. Zhang . Chemical constituents of Chrysanthemum indicum L. China J. Chinese Mater. Med. 35: 718–721, 2010. Google Scholar
Feng, X., X. Wang, Y. Liu and X. Di . Linarin inhibits the acetylcholinesterase activity in-vitro and ex-vivo. Iranian J. Pharm. Res. 14: 949–954, 2015. Medline, Web of Science, Google Scholar
Fernández, S., C. Wasowski, A.C. Paladini and M. Marder . Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacol. Biochem. Behav. 77: 399–404, 2004. Medline, Web of Science, Google Scholar
Flora of China Editorial Committee. Flora of China 20–21: 669–671, 2008, http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=220002857. Google Scholar
Gao, M.H., H. Li, Z. Li and S.X. Xiao . Studie son chemical constituents from flowers of Chrysanthemum indicum. J. Chinese Med. Mater. 31: 682–684, 2008. Google Scholar
Gu, Q., Y.Y. Chen, H. Cui, D. Huang, J.W. Zhou, T.Z. Wu, Y.P. Chen, L.N. Shi and J. Xu . Chrysanolide A, an unprecedented sesquiterpenoid trimer from the flowers of Chrysanthemum indicum L. RSC Adv. 3: 10168–10172, 2013. Web of Science, Google Scholar
Guo, Q.S., H.L. Fang and H.J. Shen . Determination of chlorogenic acid, cafeic acid and linarin in Flos Chrysanthemi Indici from different places by RP-HPLC. China J. Chinese Mater. Med. 35: 1160–1163, 2010. Google Scholar
Han, X., Y.C. Wu, M. Meng, Q.S. Sun, S.M. Gao and H. Sun . Linarin prevents LPS-induced acute lung injury by suppressing oxidative stress and inflammation via inhibition of TXNIP/NLRP3 and NF- $κ$ B pathways. Int. J. Mol. Med. 42: 1460–1472, 2018. Medline, Web of Science, Google Scholar
Hausen, B., K. Schulz, O. Jarchow, K. Klaska and H. Schmalle . A first allergenic sesquiterpene lactone from Chrysanthemum indicum L.: Arteglasin-A. Naturwissenschaften 62: 585–586, 1975. Medline, Web of Science, Google Scholar
Jiang, Y., X. Ji, L. Duan, P. Ye, J. Yang, R. Zhan, W. Chen and D. Ma . Gene mining and identification of a flavone synthase II involved in flavones biosynthesis by transcriptomic analysis and targeted flavonoid profiling in Chrysanthemum indicum L. Ind. Crop. Prod. 134: 244–256, 2019. Web of Science, Google Scholar
Jin, S.R., B.D. Zhu and X.H. Qin . Effects of Chrysanthemum indicum injection on proliferation of human tumor cells SMMC7721, PC3 and HL60. Pharm. Clin. Chinese Mater. Med. 21: 39–40, 2005. Google Scholar
Jung, E.K. Chemical composition and antimicrobial activity of the essential oil of Chrysanthemum indicum against oral bacteria. J. Bacteriol. Virol. 39: 61–69, 2009. Google Scholar
Kang, S.C., S.Y. Lim and Y.-J. Song . Lupeol is one of active components in the extract of Chrysanthemum indicum Linne that inhibits LMP1-induced NF- $κ$ B activation. PLoS One 8: e82688, 2013. Medline, Web of Science, Google Scholar
Kato, T., K. Noguchi, Y. Miyamoto, M. Suekawa, M. Aburada, E. Hosoya and M. Sakanashi . Effects of Chrysanthemum indicum Linn. on coronary, vertebral, renal and aortic blood flows of the anesthetized dog. Arch. Int. Pharm. Ther. 285: 288–300, 1987. Medline, Google Scholar
Kim, B., J.H. Lee, M.J. Seo, S.H. Eom and W. Kim . Linarin down-regulates phagocytosis, pro-inflammatory cytokine production, and activation marker expression in RAW264.7 macrophages. Food Sci. Biotechnol. 25: 1437–1442, 2016. Medline, Web of Science, Google Scholar
Kim, C., M.C. Kim, S.M. Kim, D. Nam, S.H. Choi, S.H. Kim, K.S. Ahn, E.H. Lee, J.S. Hoon and K.S. Ahn . Chrysanthemum indicum L. extract induces apoptosis through suppression of constitutive STAT3 activation in human prostate cancer DU145 cells. Phytother. Res. 27: 30–38, 2013. Medline, Web of Science, Google Scholar
Kim, D.S., Y.M. Goo, J.J. Cho, J.Y. Lee, D. Lee, S. Sin, Y. Kil, W. Jeong, K. Ko and K. Yang . Effect of volatile organic chemicals in Chrysanthemum indicum Linné on blood pressure and electroencephalogram. Molecules 23: 2063, 2018. Web of Science, Google Scholar
Kim, I.H., T.K. Lee, J.H. Cho, J.C. Lee, J.H. Park, J.H. Ahn, B.N. Shin, B.H. Chen, H.J. Tae and Y.H. Kim . Pre-treatment with Chrysanthemum indicum Linné extract protects pyramidal neurons from transient cerebral ischemia via increasing antioxidants in the gerbil hippocampal CA1 region. Mol. Med. Rep. 16: 133–142, 2017. Medline, Web of Science, Google Scholar
Kim, I.S., H.M. Ko, S. Koppula, B.W. Kim and D.K. Choi . Protective effect of Chrysanthemum indicum Linne against 1-methyl-4-phenylpridinium ion and lipopolysaccharide-induced cytotoxicity in cellular model of Parkinson’s disease. Food Chem. Toxicol. 49: 963–973, 2011. Medline, Web of Science, Google Scholar
Kim, J.E., S.J. Jun, M. Song, J.H. Kim and Y.J. Song . The extract of Chrysanthemum indicum Linne inhibits EBV LMP1-induced NF- $κ$ B activation and the viability of EBV-transformed lymphoblastoid cell lines. Food Chem. Toxicol. 50: 1524–1528, 2012a. Medline, Web of Science, Google Scholar
Kim, W.W., A.K. Ghimeray, J.C. Wu, S.H. Eom, B.G. Lee, W.S. Kang and D.H. Cho . Effect of far infrared drying on antioxidant property, anti-inflammatory activity, and inhibitory activity in A549 cells of Gamguk (Chrysanthemum indicum L.) flower. Food Sci. Biotechnol. 21: 261–265, 2012b. Web of Science, Google Scholar
Kong, L.D., Y. Cai, W.W. Huang, C.H.K. Cheng and R.X. Tan . Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout. J. Ethnopharmacol. 73: 199–207, 2000. Medline, Web of Science, Google Scholar
Lee, D.Y., G. Choi, T. Yoon, M.S. Cheon, B.K. Choo and H.K. Kim . Anti-inflammatory activity of Chrysanthemum indicum extract in acute and chronic cutaneous inflammation. J. Ethnopharmacol. 123: 149–154, 2009. Medline, Web of Science, Google Scholar
Lee, B.H., T.G. Nam, W.J. Park, H. Kang, H.J. Heo, D.K. Chung, G.H. Kim and D.-O. Kim . Antioxidative and neuroprotective effects of volatile components in essential oils from Chrysanthemum indicum Linné flowers. Food Sci. Biotechnol. 24: 717–723, 2015. Web of Science, Google Scholar
Lee, Y.S., E.J. Son, S.H. Kim, Y.M. Lee, O.S. Kim and D.S. Kim . Synergistic uric acid-lowering effects of the combination of Chrysanthemum indicum Linne flower and Cinnamomum cassia (L.) J. persl bark extracts. Evid.-Based Complement Altern. Med. 2017: 9764843, 2017. Medline, Web of Science, Google Scholar
Lee, B., C.Y. Kwon and G.T. Chang . Oriental herbal medicine for neurological disorders in children: An overview of systematic reviews. Am. J. Chin. Med. 46: 1701–1726, 2018a. Link, Web of Science, Google Scholar
Lee, Y.S., S.H. Kim, H. Yuk and D.S. Kim . DKB114, a mixture of Chrysanthemum indicum Linne flower and Cinnamomum cassia (L.) J. presl bark extracts, improves hyperuricemia through inhibition of xanthine oxidase activity and increasing urine excretion. Nutrients 10: 1381, 2018b. Web of Science, Google Scholar
Li, Z.F., Z.D. Wang, Y.Y. Ji, S. Zhang, C. Huang, J. Li and X.M. Xia . Induction of apoptosis and cell cycle arrest in human HCC MHCC97H cells with Chrysanthemum indicum extract. World J. Gastroenterol. 15: 4538–4546, 2009. Medline, Web of Science, Google Scholar
Li, Q.J. Studies on chemical constituents of Chrysanthemum indicum. Chinese J. Clin. Rat. Drug Use 04: 65–66, 2011. Google Scholar
Li, J., L. Hao, J. Wu, J. Zhang and J. Su . Linarin promotes osteogenic differentiation by activating the BMP-2/RUNX2 pathway via protein kinase A signaling. Int. J. Mol. Med. 37: 901–910, 2016. Medline, Web of Science, Google Scholar
Liu, L.L. Studies on sesquiterpenoids and other constituents of three herbal medicines from asteraceae. Lanzhou University, 2011. Google Scholar
Liu, L.L., R. Wang and Y.P. Shi . Chrysindins A-D, polyacetylenes from the flowers of Chrysanthemum indicum. Planta Med. 77: 1806–1810, 2011. Medline, Web of Science, Google Scholar
Liu, L.L., R. Wang, J.L. Yang and Y.P. Shi . Five new sesquiterpenoids from Chrysanthemum indicum. Chinese J. Chem. 30: 1255–1260, 2012. Web of Science, Google Scholar
Liu, L.L., T.K.Q. Ha, W. Ha, W.K. Oh, J.L. Yang and Y.P. Shi . Sesquiterpenoids with various carbocyclic skeletons from the flowers of Chrysanthemum indicum. J. Nat. Prod. 80: 298–307, 2017. Medline, Web of Science, Google Scholar
Lou, H., P. Fan, R.G. Perez and H. Lou . Neuroprotective effects of linarin through activation of the PI3K/Akt pathway in amyloid- $β$ -induced neuronal cell death. Bio. Med. Chem. 19: 4021–4027, 2011. Medline, Web of Science, Google Scholar
Luo, P., Y. Cheng, Z. Yin, C. Li, J. Xu and Q. Gu . Monomeric and dimeric cytotoxic guaianolide-type sesquiterpenoids from the aerial parts of Chrysanthemum indicum. J. Nat. Prod. 82: 349–357, 2019. Medline, Web of Science, Google Scholar
Luyen, B.T.T., B.H. Tai, N.P. Thao, J.Y. Cha, H.Y. Lee, Y.M. Lee and Y.H. Kim . Anti-inflammatory components of Chrysanthemum indicum flowers. Bioorg. Med. Chem. Lett. 25: 266–269, 2015. Medline, Web of Science, Google Scholar
Luyen, B.T.T., B.H. Tai, N.P. Thao, Y.M. Lee, S.H. Lee, H.D. Jang and Y.H. Kim . The anti-osteoporosis and antioxidant activities of chemical constituents from Chrysanthemum indicum flowers. Phytother. Res. 29: 540–548, 2015. Medline, Web of Science, Google Scholar
Martínez Vázquez, M., T.O. Ramírez Apan, H. Aguilar and R. Bye . Analgesic and antipyretic activities of an aqueous extract and of the flavone linarin of Buddleia cordata. Planta Med. 62: 137–140, 1996. Medline, Web of Science, Google Scholar
Matsuda, H., T. Morikawa, I. Toguchida, S. Harima and M. Yoshikawa . Medicinal flowers. VI. Absolute stereostructures of two new flavanone glycosides and a phenylbutanoid glycoside from the flowers of Chrysanthemum indicum L.: Their inhibitory activities for rat lens aldose reductase. Chem. Pharm. Bull. 50: 972–975, 2002. Medline, Web of Science, Google Scholar
Meng, Q.Y., F.U. Ling, G. Zhen, F. Yin, H.C. Yao and B.I. Yue-Feng . Comparison on different extraction processes of total flavonoids in Chrysanthemum indicum and its anti-oxidant effect. Chinese Tradit. Herb. Drug 46: 3194–3197, 2015. Google Scholar
Ming, K., Y. Chen, J. Shi, J. Yang, F. Yao, H. Du, W. Zhang, J. Bai, J. Liu and D. Wang . Effects of Chrysanthemum indicum polysaccharide and its phosphate on anti-duck hepatitis a virus and alleviating hepatic injury. Int. J. Biol. Macromol. 102: 813–821, 2017. Medline, Web of Science, Google Scholar
Mladenova, K., E. Tsankova and B. Stoianova-Ivanova . Sesquiterpene lactones from Chrysanthemum indicum. Planta Med. 51: 284–285, 1985. Web of Science, Google Scholar
Mladenova, K., E. Tsankova, I. Kostova and B. Stoianova-Ivanova . Indicumenone, a new bisabolane ketodiol from Chrysanthemum indicum. Planta Med. 53: 118–119, 1987. Medline, Web of Science, Google Scholar
Mladenova, K., E. Tsankova and H.D. Van . New sesquiterpenoids from Chrysanthemum indicum var. tuneful. Planta Med. 54: 553–555, 1988. Medline, Web of Science, Google Scholar
Myeong Sook, C., Y. Taesook, L. Do Yeon, C. Goya, M. Byeong Cheol, L. A-Yeong, C. Byung Kil and K. Ho Kyoung . Chrysanthemum indicum Linné extract inhibits the inflammatory response by suppressing NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages. J. Ethnopharmacol. 122: 473–477, 2009. Medline, Web of Science, Google Scholar
Nepali, S., J.Y. Cha, H.H. Ki, H.Y. Lee, Y.H. Kim, D.K. Kim, B.J. Song and Y.M. Lee . Chrysanthemum indicum inhibits adipogenesis and activates the AMPK pathway in high-fat-diet-induced obese mice. Am. J. Chin. Med. 46: 119–136, 2018. Link, Web of Science, Google Scholar
Nikolova, M. and A. Dzhurmanski . Evaluation of free radical scavenging capacity of extracts from cultivated plants. Biotechnol. Biotec. Eq. 23: 109–111, 2009. Web of Science, Google Scholar
Pongjit, K., C. Ninsontia, C. Chaotham and P. Chanvorachote . Protective effect of Glycine max and Chrysanthemum indicum extracts against cisplatin-induced renal epithelial cell death. Hum. Exp. Toxicol. 30: 1931–1944, 2011. Medline, Web of Science, Google Scholar
Ren, A.N., Z.G. Wang, Z.C. Lu, L.W. Wang and Y.L. Wu . Study on bacteriostasis and antivirotic activity of flosChrysanthemum indici. Pharm. Biotechno. 6: 241–244, 1999. Google Scholar
Ren, L., Z. Li, C. Dai, D. Zhao, Y. Wang, C. Ma and C. Liu . Chrysophanol inhibits proliferation and induces apoptosis through NF- $κ$ B/cyclin D1 and NF- $κ$ B/Bcl-2 signaling cascade in breast cancer cell lines. Mol. Med. Rep. 17: 4376–4382, 2018. Medline, Web of Science, Google Scholar
Rossato, M.F., G. Trevisan, C.I. Walker, J.Z. Klafke, A.P. de Oliveira, J.G. Villarinho, R.B. Zanon, L.F. Royes, M.L. Athayde and M.V. Gomez . Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem. Pharm. 81: 544–551, 2011. Medline, Web of Science, Google Scholar
Sang, J.C., M.K. Sang, T.J. Yong and H.S. Chi . Hepatoprotective effect of water extract from Chrysanthemum indicum L. flower. Chin. Med. 8: 1–8, 2013. Medline, Web of Science, Google Scholar
Shen, Y.X. and J.M. Chen . Studies on the flavonoids from Dendranthema lavandulifolium. Acta Pharm. Sin. 451–454, 1997. Google Scholar
Sun, Y., X.B. Ma and J.X. Liu . Compounds from fraction with cardiovascular activity of Chrysanthemum indicum. China J. Chinese Mater. Med. 37: 61–65, 2012. Google Scholar
Tan, X.J., Y. Jia, X.H. Chen and K.S. Bi . Determination of content of linarin in Flos Chrysanthemi Indici by RP-HPLC. J. Shenyang Pharm. Univ. 21: 434–435, 2004. Google Scholar
Tang, Y., M.H. Gao and M.C. Yao . Studies on Flavones from Flos Chrysanthemi Indici. J. Chinese Med. Mater. 32: 1532–1534, 2009. Google Scholar
Wang, G.P. Identification characteristics of effective components from Chrysanthemum indicum. Beijing Univ. Chin. Med. 2006. Google Scholar
Wang, Z.G. and A.N. Ren . Experimental study on anti-inflammatory and immune effects of Chrysanthemum indicum. Chinese J. Tradit. Med. Sci. Technol. 7: 92–93, 2000. Google Scholar
Wang, X.L., S.L. Peng, J. Liang and K.B. Yu . (3 beta, 5 alpha, 6 beta, 7 beta, 14 beta)-eudesmen-3,5,6,11-tetrol methanol solvate: A new sesquiterpenoid from Chrysanthemum indicum L. Acta Crystallogr. E62: o3570–o3571, 2006. Google Scholar
Wang, X.B., H.Y. Zhang, D.H. Xu, B.A. Cui, X.J. Cheng, X. Li and J. Ma . Effects of several chinese tradional medicine extracts on several fowl viruses in chicken embryo. Chinese Agr. Sci. Bull. 25: 5–9, 2009. Google Scholar
Wang, J.Y., D. Chen, L.J. Liang, P.F. Xue and P.F. Tu . Chemical constituents from flowers of Chrysanthemum indicum. China J. Chinese Mater. Med. 35: 718–721, 2010. Google Scholar
Wang, J.S., J. Zhou and L.Y. Kong . Three new germacrane-type sesquiterpene stereoisomers from the flowers of Chrysanthemum indicum. Fitoterapia 83: 1675–1679, 2012. Medline, Web of Science, Google Scholar
Wang, Z.J., X.Q. Meng, W.Y. Liu, J.H. Yan, J.H. Xu, L.H. Xu and Y.F. Bi . Effects of Yejuhuabaogan capsule on HBV and acute alcoholic liver injury in mice. J. Zhengzhou Univ. 52: 549–553, 2017. Google Scholar
Wu, X.L., X.X. Feng, C.W. Li, X.J. Zhang, Z.W. Chen, J.N. Chen, X.P. Lai, S.X. Zhang, Y.C. Li and Z.R. Su . The protective effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum against lipopolysaccharide-induced acute lung injury in mice via modulating Toll-like receptor 4 signaling pathway. Mediat. Inflamm. 2014: 246407, 2014. Medline, Web of Science, Google Scholar
Wu, X.S., J. Xu, T.J. Zhang and C.Q. Chen . Research progress in chemical constituents of Chrysanthemum indicum and their quality assessment. Chin. Tradit. Herb. Drug 46: 443–452, 2015. Google Scholar
Wu, T.Z., C. Jiang, L. Wang, N. Morris, S.L.H. Miao, L. Gu, J. Xu, K.H. Lee and Q. Gu . 3, 5-Diarylpyrazole derivatives obtained by ammonolysis of the total flavonoids from Chrysanthemum indicum extract show potential for the treatment of Alzheimer’s disease. J. Nat. Prod. 78: 1593–1599, 2015. Medline, Web of Science, Google Scholar
Xu, Z.H., Y.Y. Gao, H.T. Zhang, K.F. Ruan and Y. Feng . Progress in experimental and clinical research of the diabetic retinopathy treatment using traditional Chinese medicine. Am. J. Chin. Med. 1–27, 2018. Web of Science, Google Scholar
Xue, G.M., X.Q. Li, C. Chen, K. Chen, X.B. Wang, Y.C. Gu, J.G. Luo and L.Y. Kong . Highly oxidized guaianolide Sesquiterpenoids with potential anti-inflammatory activity from Chrysanthemum indicum. J. Nat. Prod. 81: 378–386, 2018. Medline, Web of Science, Google Scholar
Yan, Y.C., X.E. Lou and H.D. Jiang . Experimental studies on the anti oxidation effects of water extract from Chrysanthemum indicum L. Chinese J. Mod. Appl. Pharm. 16: 16–18, 1999. Google Scholar
Yang, H.X., X.X. Zhang, X.P. Cheng, J.H. Zhai and Z.Y. Fang . Comparative on bacteriostatic efficacy of honeysuckle and wild chrysanthemum. J. Jining Med. Coll. 36: 97–99, 2013. Google Scholar
Yang, H.M., C.Y. Sun, J.L. Liang, L.Q. Xu, Z.B. Zhang, D.D. Luo, H.B. Chen, Y.Z. Huang, Q. Wang and D.Y.W. Lee . Supercritical-carbon dioxide fluid extract from Chrysanthemum indicum enhances anti-tumor effect and reduces toxicity of bleomycin in tumor-bearing mice. Int. J. Mol. Sci. 18: 465(461–415), 2017a. Web of Science, Google Scholar
Yang, W.S., D. Kim, Y.-S. Yi, J.H. Kim, H.Y. Jeong, K. Hwang, J.-H. Kim, Park and J.Y. Cho . AKT-targeted anti-inflammatory activity of the methanol extract of Chrysanthemum indicum var. albescens. J. Ethnopharmacol. 201: 82–90, 2017b. Medline, Web of Science, Google Scholar
Yang, J.L., L.L. Liu and Y.P. Shi . Two new eudesmane Sesquiterpenoids from the flowers of Chrysanthemum indicum. Nat. Prod. Bioprospect. 9: 145–148, 2019. Medline, Web of Science, Google Scholar
Yao, F. and H.B. Xu . Study on antibacterial and antiviral activities of Chrysanthemum indicum. J. Changchun Univ. Tradit. Chinese Med. 27: 298–299, 2011. Google Scholar
Yin, Q.S., S.H. Chen, M.X. Su, W.J. Mi, B. Li and G.Y. Lv . Preparative purification of linarin extracts from dendranthema indicum flowers and evaluation of its antihypertensive effect. Evid.-Based Complement Altern. 2014: 394276, 2014. Medline, Web of Science, Google Scholar
Yoshikawa, M., T. Morikawa, T. Murakami, I. Toguchida, S. Harima and H. Matsuda . Medicinal flowers. I. Aldose reductase inhibitors and three new eudesmane-type sesquiterpenes, kikkanols A, B, and C, from the flowers of Chrysanthemum indicum L. Chem. Pharm. Bull. (Tokyo) 47: 340–345, 1999. Medline, Web of Science, Google Scholar
Yoshikawa, M., T. Morikawa, I. Toguchida, S. Harima and H. Matsuda . Medicinal flowers. II. Inhibitors of nitric oxide production and absolute stereostructures of five new germacrane-type sesquiterpenes, kikkanols D, D monoacetate, E, F, and F monoacetate from the flowers of Chrysanthemum indicum L. Chem. Pharm. Bull. (Tokyo) 48: 651–656, 2000. Medline, Web of Science, Google Scholar
Yu, S.H., X. Sun, M.K. Kim, M. Akther, J.H. Han, T.Y. Kim, J. Jiang, T.B. Kang and K.H. Lee . Chrysanthemum indicum extract inhibits NLRP3 and AIM2 inflammasome activation via regulating ASC phosphorylation. J. Ethnopharmacol. 239: 111917, 2019. Medline, Web of Science, Google Scholar
Yuan, A., Z. Li, X. Li, S. Yi, S. Wang, K. Shi and J. Bian . Distinct effect of Chrysanthemum indicum Linné extracts on isoproterenol-induced growth of human hepatocellular carcinoma cells. Oncol. Rep. 22: 1357–1363, 2009. Medline, Web of Science, Google Scholar
Zhang, L.Y., G. Cosma, H. Gardner, V. Vallyathan and V. Castranova . Effect of chlorogenic acid on hydroxyl radical. Mol. Cell. Biochem. 247: 205–210, 2003. Medline, Web of Science, Google Scholar
Zhang, Z.Y., X.P. Fang, Z.H. Diao, R.H. Zeng and X.G. Mei . Anti-respiratory syncytial virus effect of the extraction of Chrysanthemum indicum in vitro. Pharm. J. Chinese People’s Liberat. Army 22: 37–40, 2006. Google Scholar
Zhang, L., L. Jun, J.Q. Wang, L.J. Xia, H. Jiang and D. Jin . The protective effects of total flavonoids Chrysanthemum indicum on CCl_4-induced acute liver injury in mice. Acta Univ. Med. Anhui 42: 412–414, 2007a. Google Scholar
Zhang, T., X.S. Chen and D.J. Lin . Determination the contents of luteolin-7-o-glucoside and buddleoside in Chrysanthemum indicum L. by RP-HPLC. China Pharm. 10: 1091–1093, 2007b. Google Scholar
Zhang, C., M.J. Qin and Y. Wang . Chemical constituents of Chrysanthemum indicum L. Pharm. Clin. Res. 17: 39–41, 2009. Google Scholar
Zhang, J.J., W.W. Lv, Y.C. Weng, Y.F. Chen and Q.C. Zhao . Antimicrobial activity and HPLC fingerprint of flavonoids in Flos Chrysanthemi Indici. J. Int. Pharm. Res. 40(6): 807–812, 2013. Google Scholar
Zhen, Z.G., S.H. Ren, H.M. Ji, J.H. Ma, X.M. Ding, F.Q. Feng, S.L. Chen, P. Zou, J.R. Ren and L. Jia . Linarin suppresses glioma through inhibition of NF-kappaB/p65 and up-regulating p53 expression in vitro and in vivo. Biomed. Pharmacother. 95: 363–374, 2017. Medline, Web of Science, Google Scholar
Zhou, J., J.S. Wang, Y. Zhang, P.R. Wang, C. Guo and L.Y. Kong . Disesquiterpenoid and sesquiterpenes from the flos of Chrysanthemum indicum. Chem. Pharm. Bull. (Tokyo) 60: 1067–1071, 2012. Medline, Web of Science, Google Scholar
Zhou, H.Y., C.S. Wu and C.G. Cheng . Studies on chemical constituents from Chrysanthemum Indicum L. Chinese J. Mod. Appl. Pharm. 30: 31–35, 2013. Google Scholar
Zhu, S.Y., Y. Yang, H.D. Yu, Y. Ying and G.L. Zou . Chemical composition and antimicrobial activity of the essential oils of Chrysanthemum indicum. J. Ethnopharmacol. 96: 151–158, 2005. Medline, Web of Science, Google Scholar