Special Issue on Nanotoxicology; Guest Editors: G. Sharma and V. KodaliNo Access

Nanotoxicology in the Skin: How Deep is the Issue?

School of Materials Science & Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore

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and

Kee Woei Ng

School of Materials Science & Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore

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https://doi.org/10.1142/S1793984414400042Cited by:10 (Source: Crossref)

Abstract

Nanotoxicology is a concern. While skin exposure is generally perceived as less hazardous than inhalation or ingestion of engineered nanoparticles, there remain significant knowledge gaps in the topic to suggest greater caution in making a conclusion. Penetration of nanoparticles across an intact skin barrier is low. However, the verdict is still out on how this will change in situations where the skin barrier is compromised. Many studies on the interaction of nanoparticles with biological systems including skin cells have been reported. Under different scenarios, nanoparticles commonly found in topical skin products have been shown to be capable of exerting a variety of toxicological influences. These influences include causing cell death, stress, inflammation and damage to DNA. While alarming, it should also be noted that there remains much confusion and contradiction in the literature due to the complexity of studying cell–nanoparticle interactions. This review aims to provide a concise perspective on our current understanding of nanotoxicology in the skin, and identify the knowledge gaps where research efforts may be focused to help clarify the uncertainties in the field.

Keywords:

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