Narrow Results

Previous studies have suggested that Taiji practice may improve immune function. This study was intended to examine whether 5 months of moderate Taiji and Qigong (TQ) practice could improve the immune response to influenza vaccine in older adults. Fifty older adults (mean age 77.2 ± 1.3 years) participated in this study (TQ N = 27; wait-list control [CON] N = 23). Baseline pre-vaccine blood samples were collected. All subjects then received the 2003–2004 influenza vaccine during the first week of the intervention. Post-vaccine blood samples were collected 3, 6 and 20 weeks post-intervention for analysis of anti-influenza hemagglutination inhibition (HI) titers. We found a significant (p < 0.05) increase in the magnitude and duration of the antibody response to influenza vaccine in TQ participants when compared to CON. The vaccination resulted in a 173, 130, and 109% increase in HI titer at 3, 6, and 20 weeks post-vaccine, respectively, in the TQ group compared to 58, 54, and 10% in CON. There was a significant between group difference at 3 and 20 weeks post-vaccine and at 20 weeks the TQ group had significantly higher titers compared to the pre-vaccine time point, whereas the CON group did not. A higher percentage of TQ subjects also responded to the influenza A strains with a protective (> 40HI) antibody response (37% TQ vs. 20% CON for the H1N1 strain and 56% TQ vs. 45% CON for the H3N2 strain), but the differences between groups were not statistically significant. Traditional TQ practice improves the antibody response to influenza vaccine in older adults, but further study is needed to determine whether the enhanced response is sufficient to provide definitive protection from influenza infection.

Some special cases of Marchuk's model of an infectious disease are studied. A paralysis effect is neglected, and the model reduces to 3 ordinary differential equations with time delay and initial data corresponding to a healthy organism infected by some dose of the antigen at time 0. It is proved that, if the immune system is very strong and the antigen reproduction rate is not too large, then every solution has a finite limit, which is equal to the stationary state describing the healthy organism. If the antigen reproduction rate is large, then all solutions have average values equal to the values corresponding to the chronic form of the disease.

Some generalizations of Marchuk's model of an infectious disease with respect to the role of interleukins are presented in this paper. Basic properties of the models are studied. Results of numerical simulations with different coefficients corresponding to the different forms of the disease are shown.

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