Narrow Results

Antibodies are responsible for antigen recognition in vertebrate organisms. Practically any molecule can be bound by antibodies. In this work structures of 73 complexes of antibodies with small antigens were taken from PDB database and compared. The main epitope of studied ligands was an aromatic ring. Antibodies bound it with a deep cavity, lying between complementary determining regions (CDR) H3 and L3 and formed by aromatic residues. In most cases the aromatic ring of ligand was placed parallel to one or two aromatic sidechains of binding site at 3.5-4 Angstrom distance. This disposition of aromatic rings is a sign of the presence of π-stacking. It was found that small ligands with aromatics area percentage > 36% predominantly form π-stacking interaction with antibodies. Most often this interaction was observed for residues in positions H33, H95, L32 and L93.

Nowadays tools based on Scanning Probe Methods (SPM) have become indispensable in a wide range of applications such as cell imaging and spectroscopy, profilometry, or surface patterning on a nanometric scale. Common to all SPM techniques is a typically slow working speed which is one of their main drawbacks. The SPM speed barrier can be improved by operating a number of probes in parallel mode. A key element when developing probe array devices is a convenient read-out system for measurements of the probe deflection. Such a read-out should be sufficiently sensitive, resistant to the working environment, and compatible with the operation of large number of probes working in parallel. In terms of fabrication, the geometrical uniformity i.e. the realisation of large numbers of identical probes, is a major concern but also the material choice compatible with high sensitivity, the detection scheme and the working environment is a challenging issue. Examples of promising applications using parallel SPM are dip-pen-nanolithography, data storage, and parallel imaging.

Previous studies have suggested that Taiji practice may improve immune function. This study was intended to examine whether 5 months of moderate Taiji and Qigong (TQ) practice could improve the immune response to influenza vaccine in older adults. Fifty older adults (mean age 77.2 ± 1.3 years) participated in this study (TQ N = 27; wait-list control [CON] N = 23). Baseline pre-vaccine blood samples were collected. All subjects then received the 2003–2004 influenza vaccine during the first week of the intervention. Post-vaccine blood samples were collected 3, 6 and 20 weeks post-intervention for analysis of anti-influenza hemagglutination inhibition (HI) titers. We found a significant (p < 0.05) increase in the magnitude and duration of the antibody response to influenza vaccine in TQ participants when compared to CON. The vaccination resulted in a 173, 130, and 109% increase in HI titer at 3, 6, and 20 weeks post-vaccine, respectively, in the TQ group compared to 58, 54, and 10% in CON. There was a significant between group difference at 3 and 20 weeks post-vaccine and at 20 weeks the TQ group had significantly higher titers compared to the pre-vaccine time point, whereas the CON group did not. A higher percentage of TQ subjects also responded to the influenza A strains with a protective (> 40HI) antibody response (37% TQ vs. 20% CON for the H1N1 strain and 56% TQ vs. 45% CON for the H3N2 strain), but the differences between groups were not statistically significant. Traditional TQ practice improves the antibody response to influenza vaccine in older adults, but further study is needed to determine whether the enhanced response is sufficient to provide definitive protection from influenza infection.

Two zinc(II) phthalocyanines (ZnPcs) were conjugated with a monoclonal antibody (MAb) directed against carcinoembryonic antigen (CEA), using an in situ activated carboxylic acid on the ZnPcs. The bioconjugate with the highest ZnPc/MAb ratio of 3 was investigated in vitro for its ability to target and fluorescently label human colorectal HT-29 cells. The ZnPc-CEA MAb 2 was observed to efficiently target HT-29 cells, about 37 times more than unconjugated ZnPc. Furthermore, in the presence of a 4-fold excess of unlabelled anti-CEA antibody, the fluorescence signal of 2 was reduced by ~90% showing that the targeting is CEA-mediated. These studies further confirm the high specificity of Pc-antibody conjugates for antigens over-expressed on tumor cells and warrant further investigations of these immunoconjugates and their derivatives for imaging of colorectal cancer.

AUSTRALIA – Successful FDA end-of-Phase-2 for Hatchtech head lice product DeOVO^™

AUSTRALIA – Senz Oncology secures seed funding for promising cancer drug.

AUSTRALIA – Geneworks develops DNA barcodes for international security.

INDIA – Stress hormones: Good or Bad for Posttraumatic Stress Disorder risk?

SINGAPORE – New study shows fertility knowledge gaps may exacerbate Singapore's declining birth rate challenge.

SINGAPORE – World's first wearable robotic device for stroke rehabilitation comes to Singapore.

SRI LANKA – Conflicting reports highlight scientific data gaps in Sri Lanka's chronic kidney disease.

EUROPE – InDex Pharmaceuticals strengthens IP position for Kappaproct.

EUROPE – Novozymes and Terranol to market advanced biofuel yeast.

EUROPE – The world's first (official) biosimilar antibody goes to… Rheumatoid Arthritis.

USA – MRI reveals brain's response to reading.

USA – Novozymes partner Chemtex receives USDA commitment to build advanced biofuels plant in United States.

USA – Fossil fuel and renewable energy subsidies on the rise.

Bionomics Acquires Melbourne-based Iliad Chemicals.

Cryptome Pharma and Xantos Biomedicine Join Forces to Validate Novel Cancer Lead.

VioQuest's New Production Facility in China.

AlphaRx Gains Access to Asian Markets Through Joint Venture with Basin Ltd.

Emcure Pharma Cooperates with Iceland's Actavis Pharma.

GSK and Japan's Eisai Pair Up to Sell Paritec in India.

KV Pharma Invests $11.3 Million in Strides Arcolab.

Lupin in Marketing Pact with Henry Schein.

Sumitomo Pharma and Protez Pharma Announce Licensing Agreement on Breakthrough Antibiotic.

Neuren Pharma — World Leader in Developing Treatment for Neurological Disorders.

Singapore's A-bio Collaborates with Novo Nordisk.

From Poisons to Pills.

AbGenomics Licenses Antibody to Boehringer Ingelheim.

Sino Cell and Taiwan Genome Sciences Team Up in Predictive Genetic Testing for the Taiwan Market.

Agilent Technologies Sells US$4 million in Equipment to CDC.

Arana Announces Issuance of Key European Patent for Evibodies.

Living Cell Technologies Reports Interim Results Showing Sustained Beneft with DIABECELL^® Implants for Insulin Dependent Diabetes.

Topical Microbicide Field Receives Boost with Human Effcacy Result.

WuXi PharmaTech Honored on the Deloitte Technology Fast 500 Asia Pacifc 2008 List for the Fifth Consecutive Year.

Syngenta Enters into Research Collaboration with Anhui Academy, China.

Bayer Schering Pharma to Invest 100 Million Euro in China to Build a Global R&D Center.

Dow AgroSciences, China National Rice Research Institute Announce Collaboration on Rice Research.

World's First Robotic Radiosurgery System Introduced at Apollo Hospitals.

Fortis Ties up with International Oncology.

Apotex and Intas Biopharma Partner to Develop Biosimilars.

Abbott Opens New Pediatric Nutrition Manufacturing Facility in Singapore.

Schering-Plough Opens First R&D Centre in Singapore.

Hyfux Still Expanding.

GSK to Commit $1.3 Million to Singapore Institute's Vaccine Development Projects.

Invida to Market Breakthrough Anti-nausea Patch in Asia Pacifc.

NUS Partners International Rice Research Institute to Address Global Food Security Challenge.

Singapore Research Organizations Team up to Advance Drug Discovery Using Brain Tumor Stem Cells.

Osteopontin: In and Out in Immunity.

The Emerging Potential of Immunoinformatics Prediction Tools.

Alchemia Collaborates on SK1.

Progen Technology Switches On Cancer Fighting Genes.

New Australian Drug Holds Hope of Major Breakthrough in Treating Terminal Blood Cancers.

Novavax and Cadila Pharmaceuticals Form Alliance.

Icon's Singapore, India Labs Get CAP Accreditation.

SIRO Clinpharm and Advanced Clinical Trial Solutions Form Strategic Alliance.

GVK Forays into Clinical Trials with Chinese Company.

iZumi Bio and Kyoto University Collaborate on iPS Cell Technology.

Vitrolife Starts a Company in Japan.

Otsuka, BMS in an Oncology Collaboration.

EnVivo, Mitsubishi to Develop Schizophrenia Drug.

PerkinElmer Announces Collaboration with Sangmyung University.

Living Cell Technologies's New Zealand Pigs Free of Viruses.

A*STAR Joins Forces with Swiss Company, Cytos, to Combat HFMD.

IBN Engineers World's First Tri-Continuous Mesoporous Silica.

Innogene Kalbiotech Pte Ltd and Info Kinetics Sdn. Bhd. Spearhead Establishment of Internationally Accredited BA/BE Studies in Indonesia.

AUSTRALIA – Australian Drug Delivery System to Kill Cancer.

AUSTRALIA – Vitamin C Helps Fight Cancer.

AUSTRALIA – Keyhole Hysterectomy Surgery Best.

AUSTRALIA – UQ and Alere Team to Develop Dengue Fever Test.

AUSTRALIA – World's Largest ADHD Study at UQ.

CHINA – Book on Chinese Patent Medicines Soon.

CHINA – China's Organ Donations on the Rise.

CHINA – Toxic Cancer-Causing Dyes Found in China Garments.

INDIA – Stereotactic Lung Radiosurgery Treatment First in India.

JAPAN – Japan Contributes $10 Million to AIDS Vaccine Development.

KOREA – UMass, Korea Explore Asian Medicinal Herbs for Diabetes.

KOREA – South Korea Industries to Invest $18.5 Billion in Clean Energy Projects.

MALAYSIA – Future Chinese Medicine Centre in Salak Tinggi.

NEW ZEALAND – Vegetable Growers Using Banned Chemical.

SINGAPORE – GIS Partners Life Technologies to Develop New DNA Sequencing Protocols.

SINGAPORE – HPB's Be Positive!

SINGAPORE – A*STAR's ICES Receives GSK-Singapore Partnership for Green & Sustainable Manufacturing Grant Award.

SINGAPORE – New Drug for Eye Disease.

SINGAPORE – Singapore to Make Smallest Biosensors in the World.

SINGAPORE – IME and Stanford University to Develop Nano Circuits Inspired by Human Brain.

TAIWAN – Scientists Reach Hybrid Sterility Breakthrough.

TAIWAN – Cooperation Agreement Between Taiwan and Malaysia Med-tech Firms Signed at BioBusiness Asia.

OTHER REGIONS — NORTH AMERICA – Researchers Discover Most Powerful HIV Antibody.

ADDF Supports Axxam to Develop Therapeutics for Alzheimer's.

Epitomics Signs Agreement with Bayer for Antibody Technology.

Sirnaomics Partners Guangdong Zhongsheng to Dvelop siRNA Therapeutics.

Jubilant, Endo Achieve Late Stage Discovery Milestone.

Merck and Hanwha Chemical Corporation Establish Global Strategic Collaboration for Biosimilar.

SIOGEN Awarded 'Most Innovative Biotech in Asia'.

GENEWIZ, Inc. and Biomatters Announce Strategic Partnership to Align DNA-Based Services and Analysis Software.

Invida Launches Atopiclair^TM, a Treatment for Atopic Dermatitis Symptoms.

Accenture Implements Nationwide Electronic Health Record System in Singapore.

A*STAR & Olympus Singapore Establish Microscopy Suite to Study Human Diseases at the Nano-level.

Mesoblast and Lonza Establish Strategic Global Manufacturing Alliance.

Alchemia Announces Initiation of Phase II Trial in Small Cell Lung Cancer.

ShangPharma Subsidiary and Jiangsu Hengrui Medicine Partner in Therapeutic Antibody Research and Development.

Pfizer And Guoyuan Form Joint Venture To Expand Development, Manufacture And Distribution Of Animal Vaccines In China.

DSM and Sinochem Group Establish Global Anti-infectives Joint Venture.

Trivitron Healthcare Partners with Hitachi Medical Systems.

Agilent Technologies and Chungnam National University Collaborate to Further Glycomics Research.

Bristol-Myers Squibb and Ono Enter into Strategic Agreement.

Clearbridge BioMedics, Abnova Corporation Announce Collaboration.

LAByrinth - Magnifying science through the lens of design and culture.

INDIA – Zinc Treatment for Infections in Children.

JAPAN – Japan Pharma Portfolio Finds Renewed Strength through Record Growth in 2012.

JAPAN – Joint Development of a Novel Lyophilized Dual Chamber Prefillable Syringe System.

JAPAN – A Genetic Alternative to Fertilizer.

SINGAPORE – Made-in-Singapore H5N1 Bird Flu Diagnostic Kit - Detects All Known Strains of H5N1 Virus with a Single Test.

THAILAND – KEEEN, Thai Bioremediation Product, Awarded Gold Medal for "Bioremediation Agent developed to Greenovation Product".

EUROPE – MorphoSys Antibody Reaches Major Milestone in Collaboration with Roche.

EUROPE – New Technique to Predict Heart Attacks.

USA – FEI Launches 'Living Lab' for Structural Biology Research at NIH.

USA – Synthetic Platelets Built to Treat Bleeding.

USA – Software Scans Tongue for Signs of Disease.

USA – US Legislation Will Ensure Tighter Checks on Foreign Drug Factories.

Agilent Technologies supports Professor's work developing transformative NMR applications for structural biology.

Alchemia announces multi-target drug discovery collaboration with AstraZeneca on VAST discovery platform.

DSM and DecImmune Therapeutics sign agreement to develop N2 pathway blocking antibody.

Novel technology from Columbia University for Neurobiological Research.

A new EU-funded industry-academia drug discovery partnership targets challenging kinases.

Avian Influenza A (H7N9) threatens, GenScript supports researchers in impending battle.

High-Throughput Sequencing on a Next Generation Sequencer to Identify Specific Binders from a Phage Library

Antibody Solution Viscosity and Intermolecular Interactions: Considerations for Development of Highly Concentrated Formulations

Display of Membrane Proteins on a Viral Envelope for Antibody Generation

Sequence and Structural Determinants of Antigen Binding in Antibody CDR Loops

Enhancement of the Stability of Single Chain Fv Molecules with the Amino Acid Substitutions Predicted by High-Performance Computer

Thermal Stability of Camelid Single Domain VHH Antibody

SINGAPORE – Singapore Scientists Provide New Insights on How Cancers Evade the Immune System.

SINGAPORE – NUS Scientists Discover Novel Vulnerabilities in Dengue Virus.

UNITED STATES – New Study Suggests that Vitamin D Decreases Risk of Cancer.

UNITED STATES – Study Reverses Thinking on Genetic Links to Stress, Depression.

UNITED STATES – Antibody Helps Detect Protein Implicated in Alzheimer’s, Other Diseases.

UNITED STATES – Fruits and Vegetables’ Latest Superpower? Lowering Blood Pressure.

AUSTRALIA & KOREA – Novotech Signs MOU with South Korea’s Leading Medical Center, the Asan Medical Center.

SINGAPORE – Asia Pacific Medical Technology Association (APACMed) Announces Partnership with Duke-NUS Medical School’s Centre of Regulatory Excellence (CoRE), Pledging Joint Commitment to Promote Regulatory Convergence and Capacity Building Across the Region.

SINGAPORE – Guardian Partners with MyDoc to Address Singapore’s Population Health Needs through Integrating Technology and Self-Care.

SINGAPORE & UNITED STATES – CellMax Life’s Precision, Non-Invasive Cancer Testing Now Available throughout Southeast Asia through Asia Genomics.

UNITED STATES – 3-D Printed Models Could Improve Patient Outcomes in Heart Valve Replacements.

UNITED STATES – Promising Target to Protect Bone in Patients with Diabetes.

UNITED STATES – New Antibody Appears to Re-Activate Immune System in Cancer Therapy.

UNITED STATES – Combo Immunotherapy May Herald New Standard of Care for Kidney Cancer.

JAPAN – Chugai’s Bispecific Antibody “Emicizumab” Global Phase III Data in Patients with Haemophilia A with Inhibitors Published in The New England Journal of Medicine Online.

RUSSIA & INDIA – BIOCAD’s Rituximab Biosimilar to Receive Market Authorization Soon in India.

How the largest birds on Earth and their strong immune systems lead to a breakthrough in antibody technology research.

Life of a Scientist at Chugai Pharmabody Research

The following topics are under this section:

• Preclinical data demonstrates favourable safety profile of novel anti-HER3 antibody
• Phase III clinical trial reveals positive results for cancer immunotherapy in treating the most common form of liver cancer
• Strategic partnership to bring hope to patients with fibrotic and inflammatory diseases
• Hong Kong’s first Mononuclear Cell Bank attains AABB accreditation
• Expanding reach of Biosimilar candidates in Taiwan and Hong Kong
• Developing Novel Cancer Therapies with Greater Precision
• Singapore-based MedTech Start-up raises US$ 4 million in funding
• Asia’s HealthTech Momentum Remains Strong at US$ 5 billion in 2019
• Emergex raises more than US$ 11 million in Series A Round
• Korean-based biotechnology company seals exclusive sales agreement