This paper addresses the issue of forward extrapolation in time of the trend of existing experimental datasets for forecast purposes. It aims to introduce difficulties and limitations intrinsic to that task also in science, quite studied but often ignored, with the consequent risk of propagating false information. Making a forecast is one of the most popular expectations from science in economics, politics, Society, and scientific and non-scientific Communities. Science is assumed to be the safest way to allow reliable predictions. However, science too, being based on experimental data or inference, can only provide such predictions within a limited level of confidence — according to its statistical meaning — so never provide certainty. Scientists, in fact, never ignore that uncertainty is always associated with all their current findings or thinking, including the possibility of (further) evolution in time. As a consequence, from uncertain time-series data, one should not be able to get a deterministic extrapolated trend supplying the full correct information. A few examples are reported taken from climate analysis results.