From the perspective of diffusion of technological innovation, a model of factors affecting the structural optimization of cultural industries was constructed using national data from 2009-2019. The results of the stepwise regression method show that patent application, patent grant, and regional GDP per capita significantly affect the structural optimization of cultural industries. Therefore, it is essential to enhance the independent innovation capability of cultural enterprises and promote the efficiency of technology achievement transformation while creating a favorable innovation environment to enhance the structural optimization of cultural industries.