Carter, Jelsovsky, Kamada, Langford and Saito introduced the quandle cocycle invariants of 2-knots, and calculated the cocycle invariant of a 2-twist-spun trefoil knot associated with a 3-cocycle of the dihedral quandle of order 3. Asami and Satoh calculated the cocycle invariants of twist-spun torus knots τrT(m,n) associated with 3-cocycles of some dihedral quandles. They used tangle diagrams of the torus knots. In this paper, we calculate the cocycle invariants of twist-spun 2-bridge knots τrS(α,β) by a similar method.