While finite elements has been considered during the last decades as the universal tool to perform simulations in biomechanics, a recently developed wide family of methods, globally coined as meshless methods, has emerged as an attractive choice for an increasing variety of engineering problems. They present some key advantages such as the absence of a mesh in the traditional sense, particularly important in domains of very complex geometry, a less sensitivity to the nodal distribution and therefore to the implicit mesh distorsion what is especially interesting to handle problems under finite strains and large displacements in a Lagrangian framework. Here, we analyze the convenience and possible advantages of using meshless methods in numerical simulations of soft biological tissues. Biological tissues are usually nonlinear, anisotropic, inhomogeneous, viscoelastic, and undergo large deformations, so these methods seem to be an appealing possibility for this type of applications. In particular, we discuss the use of one of these methods, the so-called natural element method that has specific and important features as interpolatory character, easy handling of geometry, and essential boundary conditions via the so-called alpha-NEM extension, well-defined mathematical properties and a simple computer implementation. Different examples are solved using this approach including the human cornea, the temporo-mandibular joint, knee ligaments, and the passive behavior of the heart.