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articleNo Access
Synthesis, in vitro inhibition effect of novel phthalocyanine complexes as carbonic anhydrase and paraoxonase enzyme inhibitors
Journal of Porphyrins and Phthalocyanines01 Aug 2020
Preview Abstract
The preparation and assessment of carbonic anhydrase and paraoxonase enzyme inhibition properties of 3-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)ethoxy)phthalonitrile (2) and its nitrogen-containing non-peripheral phthalocyanine derivatives (3 and 4) are reported for the first time. The new phthalonitrile and its phthalocyanine derivatives have been elucidated by FT-IR spectroscopy, ¹H-NMR, $^{13}$ $^{13}$ C-NMR, mass and UV-vis spectroscopy. The results demonstrated that all synthesized compounds moderately inhibited carbonic anhydrase and paraoxonase enzymes. Among the compounds, the most active ones were found to be compound 4 for PON (Ki : 0.14 $μ$ $μ$ M), compound 3 for hCA I (Ki : 22.52 $μ$ $μ$ M) and compound 1 for hCA II (Ki : 13.62 $μ$ $μ$ M).