Modern science has been thoroughly influenced by the centuries-old Simplicity Principle, also known as Ockham’s Razor. This principle is usually formulated as “entities must not be multiplied without necessity”. The main problem with this formulation is that the necessity or redundancy of an entity (e.g. a concept, hypothesis, law, rule, an explanatory element) cannot always be compellingly demonstrated. This means that, certainly within an empiristic, positivistic or materialistic worldview, the use of Ockham’s Razor easily tends towards unjustified reductionism. However, ontologically or epistemologically, the Simplicity Principle can no longer be justified. The Simplicity Principle does not provide a sufficient argument to reject “entities” as irrelevant or superfluous. Moreover, a reductionistic conception of science cannot contribute to tackling issues concerning ultimate values, meanings of life, metaphysics, aesthetics, religion and several aspects of practical life, such as counselling, morals, politics and jurisdiction. Therefore, this article proposes an alternative principle that I have called the Chatton–Ockham Strategy, which is an integration of Chatton’s anti-Razor and Ockham’s Razor and deals with the complexity–simplicity polarity.