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The starch wastewater has the characteristics of high concentration of COD and BOD, and good biodegradability, the UASB-CASS-Coagulation is used to the treatment of starch wastewater. The effluent treated from the system met the national standard GB8978-1996 for discharge. The application results show that the UASB-CASS-Coagulation combined process has advantages of high stability and efficiency, low running expense, utilizing the available resources, etc.