Enantioselective Titanium-Catalysed Transformations

The following sections are included:

• Contents
• General Introduction

The following sections are included:

• Introduction
• Titanium-Promoted Alkylation and Arylation Reactions of Carbonyl Compounds
  • Additions of Dialkylzinc Reagents to Carbonyl Compounds
    • Aldehydes as electrophiles
    • Ketones as electrophiles
  • Additions of Organoaluminum Reagents to Carbonyl Compounds
    • Aldehydes as electrophiles
    • Ketones as electrophiles
  • Additions of Grignard Reagents to Aldehydes
  • Additions of Organotitanium Reagents to Aldehydes
  • Additions of Alkylboron Reagents to Aldehydes
  • Additions of Organolithium Reagents to Aldehydes
• Titanium-Promoted Alkynylation Reactions of Carbonyl Compounds
  • Aldehydes as Electrophiles
    • Addition of phenylacetylene
    • Addition of various terminal alkynes
    • Addition of 1,3-diynes and 1,3-enynes
  • Ketones as Electrophiles
• Titanium-Promoted Allylation and Vinylation Reactions of Carbonyl Compounds
  • Allylations
  • Vinylations
• Conclusions
• References

The following sections are included:

• Introduction
• Aldehydes as Electrophiles
  • Cyanations of aldehydes with trimethylsilyl cyanide
    • Salen ligands
    • BINOL-derived ligands
    • Schiff base ligands
    • Other ligands
  • Cyanations of aldehydes with other sources of cyanide
    • Salen ligands
    • Other ligands
  • Ketones as Electrophiles
  • Strecker-Type Reactions
  • Conclusions
• References

The following sections are included:

• Introduction
• Alkyl Hydroperoxides as Oxidants
• Hydrogen Peroxide as Oxidant
• Conclusions
• References

The following sections are included:

• Introduction
• Epoxidations using Hydrogen Peroxide
• Epoxidations using Alkyl Hydroperoxides
• Darzens Reactions
• Conclusions
• References

The following sections are included:

• Introduction
• (Hetero)-Diels-Alder Cycloadditions
• 1,3-Dipolar Cycloadditions
• Cyclopropanations
• Conclusions
• References

This chapter covers efforts of the chemical community to develop novel enantioselective titanium-catalysed aldol-type reactions. It looks at developments since the beginning of 2008, when the field was reviewed by Yu and co-workers in a book chapter dealing with titanium Lewis acids…

The following sections are included:

• Introduction
• Hydroaminations
• Hydrophosphonylations
• Miscellaneous Reductions
• Conclusions
• References

The following sections are included:

• Introduction
• Ring-Opening Reactions of Epoxides
• Ring-Opening Reactions of Aziridines
• Conclusions
• References

This chapter covers efforts of the chemical community to develop novel enantioselective titanium-catalysed domino and tandem reactions. It looks at developments since the beginning of 2008, when the field was reviewed by Yu and co-workers in a book chapter dealing with titanium Lewis acids…

The following sections are included:

• Introduction
• Michael-Type Reactions
• Friedel–Crafts Reactions
• Other Reactions
• Conclusions
• References

The enantioselective production of compounds is a central theme in current research. The broad utility of synthetic chiral molecules as singleenantiomer pharmaceuticals; in electronic and optical devices; as components in polymers with novel properties; and as probes of biological function, has made asymmetric synthesis a prominent area of investigation. Nearly all natural products are chiral, and their physiological or pharmacological properties depend upon their recognition by chiral receptors, which will interact only with molecules of the proper absolute configuration. Indeed, the use of chiral drugs in enantiopure form is now a standard requirement for virtually every new chemical entity, and the development of new synthetic methods to obtain enantiopure compounds has become a key goal for pharmaceutical companies. The search for new and efficient methods for the synthesis of optically pure compounds constitutes an active area of research in organic synthesis…

The following sections is included:

• Index