Frontiers of Organofluorine Chemistry

The following sections are included:

• Preface
• About the Editor
• Contents
• Abbreviations

The following sections are included:

• Introduction
• Decarboxylative Fluorination
• Fluoro Functionalization of Alkenes
• Csp³–H Fluorination
• Csp²–F Bond Formation
• Metal-Catalyzed Asymmetric Reactions
• References

The following sections are included:

• Introduction
• Trifluoromethylation (–CF₃)
• Difluoromethylation (–CF₂H) and Difluoromethylenation (–CF₂–)
• Conclusion and Outlook
• Acknowledgment
• References

The following sections are included:

• Properties and the Importance of the CF₃-Group
• Impact of Electrophilic Hypervalent Iodine Trifluoromethylating Agents
• Synthesis and Structure
• Thermal Stability
• Mechanistic Diversity
• Select Synthetic Examples
• Outlook
• References

The following sections are included:

• Introduction
• Fluoroalkylations
• Fluoroalkylthiolations
• Fluoroalkylselenolations
• Summary and Outlook
• References

The following sections are included:

• Introduction
• Synthesis and Reactivity of SF₅-Bearing Aliphatic Compounds and Olefins
• Synthesis of Trifluoromethyl and Aryl-Substituted Tetrafluoro-λ⁶-sulfanes
• Utility of SF₅-Arenes in Preparation of SF₅-Aliphatic Compounds and Olefins
• Conclusion
• References

The following sections are included:

• Introduction
• The SDE Phenomenon
• Peculiarities of Fluoroorganics and Their Implications for the SDE
• SDE via Sublimation
• SDE via Distillation
• SDE via Achiral Chromatography
• Challenges and Future Prospects on SDE Research and Application
• Summary
• References

The following sections are included:

• Introduction
• Asymmetric Reaction of Fluorinated Compounds
• Enantioselective Fluorination
• Enantioselective Trifluoromethylation and Trifluoromethyl-thiolation
• References

The following sections are included:

• Introduction
• C–F Bond Activation and Formation by Transition Metal Complexes
• Reductive Elimination of C–F Bonds from [M]-fluoride Complexes
• Summary and Outlook
• References

The following sections are included:

• Introduction
• Fluorinated Matrix Metalloproteinase Inhibitors
• Conclusion and Outlook
• References

The following sections are included:

• Introduction
• Effects of Fluorine on Proteolytic Stability of Peptides and Peptidomimetics
• Conclusion
• Acknowledgments
• References

The following sections are included:

• Introduction
• Fluorinated Molecules in Chemical Biology
• Applications of Fluorinated Materials in Chemical Biology for Separation, Detection, and Delivery of Therapeutics
• Conclusion
• References

The following sections are included:

• Introduction
• Chemistry
• Enzymology
• Applications
• Engineering
• Fluorination of Natural Products
• Summary and Perspectives
• References

The following sections are included:

• Introduction
• Nucleophilic Aromatic Substitution with [¹⁸F] Fluoride Ion
• Radiofluorination of Hypervalent Iodine(III) Compounds with [¹⁸F]Fluoride
• Transition-Metal-Mediated Aromatic Fluorination with [¹⁸F]Fluoride
• Alternative Methods for Synthesis of Aryl [¹⁸F] Fluorides with [¹⁸F]Fluoride
• Conclusion and Outlook
• References

The following sections are included:

• Introduction
• ¹⁸F-Labeling of CF₃S-Motif
• Conclusions and Perspectives
• References

The following sections are included:

• Historical Overview and the Rise of Fluorine in Drugs
• Applications of Fluorine in Drug Design
• Synthesis of Fluorinated Pharmaceuticals
• Conclusions and Outlook
• References

The following sections are included:

• Introduction
• Fluorine-Containing Herbicides
• Fluorine-Containing Fungicides
• Insecticides
• Conclusion
• Acknowledgment
• References

The following sections are included:

• Introduction
• Synthesis of 2-(Trifluoromethyl) Acrylic Acid (MAF) and Alkyl 2-(Trifluoromethyl)acrylates (MAF-esters) Monomers
• Polymerization of MAF and MAF-esters
• Application of Copolymers Based on MAF and MAF-Esters Comonomers
• Conclusions
• Acknowledgments
• References

The following sections are included:

• Introduction and Scope: Could Fluorocarbon Gases Affect the Chemical Physics of an Underlying Aqueous Phase?
• Impact of Fluorocarbon Gases on Interfacial Films of Phospholipids, Surfactants, Copolymers, Amphiphilic Proteins, and Fluorinated Molecules
• Application to Fluorocarbon-Assisted Microbubble Design and Engineering
• Conclusions and Perspectives
• References

The following section is included:

• Index